Hydroxyapatite nanorod-reinforced biodegradable poly(L-lactic acid) composites for bone plate applications

Date

2011-11-01

Author

Aydin, Erkin
Planell, Josep A.
Hasırcı, Vasıf Nejat

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Novel PLLA composite fibers containing hydroxyapatite (HAp) nanorods with or without surface lactic acid grafting were produced by extrusion for use as reinforcements in PLLA-based bone plates. Fibers containing 0-50% (w/w) HAp nanorods, aligned parallel to fiber axis, were extruded. Lactic acid surface grafting of HAp nanorods (lacHAp) improved the tensile properties of composites fibers better than the non-grafted ones (nHAp). Best tensile modulus values of 2.59, 2.49, and 4.12 GPa were obtained for loadings (w/w) with 30% lacHAp, 10% nHAp, and 50% amorphous HAp nanoparticles, respectively. Bone plates reinforced with parallel rows of these composite fibers were molded by melt pressing. The best compressive properties for plates were obtained with nHAp reinforcement (1.31 GPa Young's Modulus, 110.3 MPa compressive strength). In vitro testing with osteoblasts showed good cellular attachment and spreading on composite fibers. In situ degradation tests revealed faster degradation rates with increasing HAp content. To our knowledge, this is the first study containing calcium phosphate-polymer nanocomposite fibers for reinforcement of a biodegradable bone plate or other such implants and this biomimetic design was concluded to have potential for production of polymer-based biodegradable bone plates even for load bearing applications.

Subject Keywords

Poly-l-lactide, Mechanical-properties, In-vitro, Polylactic acid, Part 1, Particles, Fixation, Behavior, Devices, Tissue

URI

https://hdl.handle.net/11511/31523

Journal

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE

DOI

https://doi.org/10.1007/s10856-011-4435-z

Collections

Graduate School of Natural and Applied Sciences, Article

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Citation Formats

E. Aydin, J. A. Planell, and V. N. Hasırcı, “Hydroxyapatite nanorod-reinforced biodegradable poly(L-lactic acid) composites for bone plate applications,” JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, pp. 2413–2427, 2011, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/31523.