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Hydroxyapatite nanorod-reinforced biodegradable poly(L-lactic acid) composites for bone plate applications
Date
2011-11-01
Author
Aydin, Erkin
Planell, Josep A.
Hasırcı, Vasıf Nejat
Metadata
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Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
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Novel PLLA composite fibers containing hydroxyapatite (HAp) nanorods with or without surface lactic acid grafting were produced by extrusion for use as reinforcements in PLLA-based bone plates. Fibers containing 0-50% (w/w) HAp nanorods, aligned parallel to fiber axis, were extruded. Lactic acid surface grafting of HAp nanorods (lacHAp) improved the tensile properties of composites fibers better than the non-grafted ones (nHAp). Best tensile modulus values of 2.59, 2.49, and 4.12 GPa were obtained for loadings (w/w) with 30% lacHAp, 10% nHAp, and 50% amorphous HAp nanoparticles, respectively. Bone plates reinforced with parallel rows of these composite fibers were molded by melt pressing. The best compressive properties for plates were obtained with nHAp reinforcement (1.31 GPa Young's Modulus, 110.3 MPa compressive strength). In vitro testing with osteoblasts showed good cellular attachment and spreading on composite fibers. In situ degradation tests revealed faster degradation rates with increasing HAp content. To our knowledge, this is the first study containing calcium phosphate-polymer nanocomposite fibers for reinforcement of a biodegradable bone plate or other such implants and this biomimetic design was concluded to have potential for production of polymer-based biodegradable bone plates even for load bearing applications.
Subject Keywords
Poly-l-lactide
,
Mechanical-properties
,
In-vitro
,
Polylactic acid
,
Part 1
,
Particles
,
Fixation
,
Behavior
,
Devices
,
Tissue
URI
https://hdl.handle.net/11511/31523
Journal
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
DOI
https://doi.org/10.1007/s10856-011-4435-z
Collections
Graduate School of Natural and Applied Sciences, Article
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E. Aydin, J. A. Planell, and V. N. Hasırcı, “Hydroxyapatite nanorod-reinforced biodegradable poly(L-lactic acid) composites for bone plate applications,”
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
, pp. 2413–2427, 2011, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/31523.