Preparation and evaluation of polymer based microcarriers for all-trans-retinoic acid

Date

2013-09-01

Author

Daskin, Demet
Gündüz, Ufuk

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Polymeric biomaterials are being investigated for the last several years because of their controllable properties. In this study, it was aimed to prepare and evaluate the atRA carrying system using Poly(lactide-co-glycolide) (PLGA). Microparticles were characterized in terms of morphology and encapsulation efficiency. Release studies were performed for the evaluation of drug release rates. Cytotoxicity tests were implemented on MCF-7 Human breast cancer cell line for the investigation of drug and polymer toxicity. The microparticles were found smooth and spherical in shape. However, as the loaded drug amount increased, the sizes of microparticles also increased and the size distribution became less uniform. The sizes of atRA-loaded microparticles ranged between 1-10 mu m. The encapsulation efficiency of atRetinoic acid (all-trans-Retinoic acid) was achieved approximately %90. Approximately, 45% of atRA was released from atRA-loaded microparticles by the end of 4-5 days. Cell growth inhibition was observed after 4 days of incubation of cells with PLGA microparticles.

Subject Keywords

All-Trans-retinoic acid, Poly(D,L-lactide-co-glycolide), Microparticles, Polimeric drug carrier, Drug delivery

URI

https://hdl.handle.net/11511/31739

Journal

PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY

DOI

https://doi.org/10.3109/10837450.2011.644296

Collections

Graduate School of Natural and Applied Sciences, Article

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Citation Formats

D. Daskin and U. Gündüz, “Preparation and evaluation of polymer based microcarriers for all-trans-retinoic acid,” PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY, pp. 1017–1025, 2013, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/31739.