Identification of computational hot spots in protein interfaces: combining solvent accessibility and inter-residue potentials improves the accuracy

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2009-06-15

Author

Tunçbağ, Nurcan
Keskin, Ozlem

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Motivation: Hot spots are residues comprising only a small fraction of interfaces yet accounting for the majority of the binding energy. These residues are critical in understanding the principles of protein interactions. Experimental studies like alanine scanning mutagenesis require significant effort; therefore, there is a need for computational methods to predict hot spots in protein interfaces.

Subject Keywords

Globular-Proteins, Subunit İnterfaces, Receptor Complex, Binding-Energy, Sequence, Prediction, Conservation, Database, Hormone

URI

https://hdl.handle.net/11511/32060

Journal

BIOINFORMATICS

DOI

https://doi.org/10.1093/bioinformatics/btp240

Collections

Graduate School of Informatics, Article

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Citation Formats

N. Tunçbağ and O. Keskin, “Identification of computational hot spots in protein interfaces: combining solvent accessibility and inter-residue potentials improves the accuracy,” BIOINFORMATICS, pp. 1513–1520, 2009, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/32060.