Creatinine Deiminase Adsorption onto Silicalite-Modified pH-FET for Creation of New Creatinine-Sensitive Biosensor

2016-03-31
Marchenko, Svitlana V.
Soldatkin, Oleksandr O.
Kasap, Berna Ozansoy
Akata Kurç, Burcu
Soldatkin, Alexei P.
Dzyadevych, Sergei V.
In the work, silicalite particles were used for the surface modification of pH-sensitive field-effect transistors (pH-FETs) with the purpose of developing new creatinine-sensitive biosensor. Creatinine deiminase (CD) adsorbed on the surface of silicalite-coated pH-FET served as a bioselective membrane. The biosensor based on CD immobilized in glutaraldehycie vapor (GA) was taken as control. The creatinine-sensitive biosensor obtained by adsorption on silicalite was shown to have better analytical characteristics (two-to threefold increased sensitivity to creatinine, three-to fourfold lesser response and recovery times, a decrease of the detection limit of creatinine determination to 5 mu m, etc.).

Citation Formats
S. V. Marchenko, O. O. Soldatkin, B. O. Kasap, B. Akata Kurç, A. P. Soldatkin, and S. V. Dzyadevych, “Creatinine Deiminase Adsorption onto Silicalite-Modified pH-FET for Creation of New Creatinine-Sensitive Biosensor,” NANOSCALE RESEARCH LETTERS, vol. 11, pp. 0–0, 2016, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/32211.