Chondroitin sulfate-coated polyhydroxyethyl methacrylate membrane prevents adhesion in full-thickness tendon tears of rabbits

Date

2002-03-01

Author

Gudemez, E
Eksioglu, F
Korkusuz, P
Asan, E
Gursel, I
Hasırcı, Vasıf Nejat

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Polyhydroxyethyl methacrylate (pHEMA) membranes coated on one side with chondroitin sulfate (CS) were used to block adhesion physically and to reduce friction between healing flexor tendons and the surrounding tissue in rabbit forepaws after surgical repair. Digits with pHEMA-only, standard tendon sheath repair, and with no sheath repair were the controls. Over 12 weeks the CS-coated membranes were evaluated for joint flexion, adhesion limitation, and tendon healing progress. The membranes initially allowed for better flexion (i.e, for 6 weeks), but their relative superior effectiveness faded afterward. Histology showed that adhesions were less severe and healing was better in the CS-pHEMA membranes at 3 and 6 weeks. If further studies determine precise amounts or thicknesses of CS coats that will maximize its healing properties, CS-pHEMA should prove useful in clinical settings in which restoration of tendon sheath integrity with a minimum of adhesions is not possible. Copyright (C) 2002 by the American Society for Surgery of the Hand.

Subject Keywords

Tendon injuries, Adhesion, Polyhydroxyethyl methacrylate (pHEMA), Chondroitin sulfate

URI

https://hdl.handle.net/11511/32232

Journal

JOURNAL OF HAND SURGERY-AMERICAN VOLUME

DOI

https://doi.org/10.1053/jhsu.2002.31161

Collections

Graduate School of Natural and Applied Sciences, Article

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Citation Formats

E. Gudemez, F. Eksioglu, P. Korkusuz, E. Asan, I. Gursel, and V. N. Hasırcı, “Chondroitin sulfate-coated polyhydroxyethyl methacrylate membrane prevents adhesion in full-thickness tendon tears of rabbits,” JOURNAL OF HAND SURGERY-AMERICAN VOLUME, pp. 293–306, 2002, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/32232.