Proteome-wide analysis of pleiotropic effects of targeted homoserine dehydrogenase (hom) gene disruption in Streptomyces clavuligerus

Date

2018-10-10

Author

Zcengiz, G.
Nsaldi, E.
Aktas, C.
Ertekin, Ozan
KURT KIZILDOĞAN, ASLIHAN
Zcan, S.

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URI

https://hdl.handle.net/11511/32781

Journal

NEW BIOTECHNOLOGY

DOI

https://doi.org/10.1016/j.nbt.2018.05.1006

Collections

Department of Biology, Article

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Proteome-wide analysis of the functional roles of bacilysin biosynthesis in Bacillus subtilis Özcengiz, Gülay; Demir, Mustafa; Karatas, Ayten Yazgan (2014-07-01) The members of the genus Bacillus produce a wide variety of secondary metabolites with antimetabolic and pharmacological activities. Most of these metabolites are small peptides that have unusual components and chemical bonds and synthesized nonribosomally by multifunctional enzyme complexes called peptide synthetases. Bacilysin, being produced and excreted by certain strains of Bacillus subtilis, is one of the simplest peptide antibiotics known. It is a dipeptide with an N-terminal Lalanine and an unusual ...
Proteome-wide analysis of the functional roles of Bacilysin biosynthesis in Bacillus subtilis Taşkın Aras, Aslı; Özcengiz, Gülay; Department of Biology (2010) The members of the genus Bacillus produce a wide variety of secondary metabolites with antimetabolic and pharmacological activities. Most of these metabolites are small peptides that have unusual components and chemical bonds and synthesized nonribosomally by multifunctional enzyme complexes called peptide synthetases. Bacilysin, being produced and excreted by certain strains of Bacillus subtilis, is one of the simplest peptide antibiotics known. It is a dipeptide with an N-terminal L-alanine and an unusual...
Proteome-wide alterations in an industrial clavulanic acid producing strain of Streptomyces clavuligerus Unsaldi, Eser; Kurt-Kizildogan, Aslihan; Voigt, Birgit; Becher, Doerte; Özcengiz, Gülay (2017-03-01) The usefulness of genetic/metabolic engineering for further improvement of industrial strains is subject of discussion because of the general lack of knowledge on genetic alterations introduced by iterative cycles of random mutagenesis in such strains. An industrial clavulanic acid (CA)-overproducer Streptomyces clavuligerus DEPA was assessed to understand proteome-wide changes that have occurred in a local industrial CA overproducer developed through succesive mutagenesis programs. The proteins that could ...

Citation Formats

G. Zcengiz, E. Nsaldi, C. Aktas, O. Ertekin, A. KURT KIZILDOĞAN, and S. Zcan, “Proteome-wide analysis of pleiotropic effects of targeted homoserine dehydrogenase (hom) gene disruption in Streptomyces clavuligerus,” NEW BIOTECHNOLOGY, pp. 0–0, 2018, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/32781.