Esra Sinoplu

E-mail

esra@metu.edu.tr

Department

Graduate School of Informatics

ORCID

0000-0002-4051-9793

Scopus Author ID

57204015514

Web of Science Researcher ID

AAB-9228-2020

Repurposing Drugs to Target Molecular Networks in Hepatocellular Carcinoma Cells & Stem Cells for Innovative Treatment Strategies Sinoplu, Esra; TUNÇBAĞ, NURCAN; Kahraman, Deniz Cansen; ATALAY, RENGÜL (2023-12-01)
Exploring novel vicinal diaryl-substituted isoxazole and pyrazole derivatives as cytotoxic compounds for targeting breast cancer: Mechanisms and therapeutic potential Sinoplu, Esra; GÜNTEKİN ERGÜN, SEZEN; TURANLI, SÜMEYYE; LENGERLİ, DENİZ; ÇALIŞKAN, BURCU; BANOĞLU, ERDEN; ATALAY, RENGÜL (2023-10-30)
Network-based in silico modeling for drug repurposing and in vitro validation in hepatocellular carcinoma Sinoplu, Esra; Tunçbağ, Nurcan; Atalay, Rengül (2022-10-25)
Synthesis and Biological Evaluation of Novel Isoxazole-Piperazine Hybrids as Potential Anticancer Agents with Inhibitory Effects on Liver Cancer Stem Cells İbiş, Kübra; Sinoplu, Esra; Çalışkan, Burcu; Atalay, Rengül; Banoğlu, Erden (2022-08-29)
BAZI VİSİNAL DİARİL HETEROSİKLİK BİLEŞİKLERİN ANTİKANSER AKTİVİTELERİNİN ARAŞTIRILMASI Turanlı, Sümeyye; Sinoplu, Esra; Akhan Güzelcan, Ece; Atalay, Rengül; Çalışkan, Burcu; Banoğlu, Erden (2022-08-26)
Identification of undefined off-targets of novel drugs and drug combinations with network-based in silico modeling and in vitro validation in hepatocellular carcinoma Sinoplu, Esra; Tunçbağ, Nurcan; Atalay, Rengül (2022-06-24) Introduction Hepatocellular carcinoma (HCC) is one of the most common and deadliest cancer worldwide. It is highly resistant to conventional chemotherapies due to the hyperactivation of many critical survival signaling ...
Anticancer activity of novel vicinal diaryl isoxazole compounds in hepatocellular carcinoma Sinoplu, Esra; Akhan Güzelcan, Ece; Turanlı, Sümeyye; Lengerli, Deniz; Çalışkan, Burcu; Banoğlu, Erden; Atalay, Rengül (2022-02-04) Background and Aims Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer and 2nd lethal cancer in the world. The global burden of HCC is expected to increase in the next decade due to the increa...
Data Centric Molecular Analysis and Evaluation of Hepatocellular Carcinoma Therapeutics Using Machine Intelligence-Based Tools Cetin-Atalay, Rengul; Kahraman, Deniz Cansen; Sinoplu, Esra; RİFAİOĞLU, AHMET SÜREYYA; Atakan, Ahmet; Dönmez, Ataberk; Atas, Heval; Atalay, Mehmet Volkan; Acar, Aybar C.; DOĞAN, TUNCA (2021-12-01) Purpose Computational approaches have been used at different stages of drug development with the purpose of decreasing the time and cost of conventional experimental procedures. Lately, techniques mainly developed and appl...
Synthesis and biological evaluation of novel isoxazole-piperazine hybrids as potential anti-cancer agents with inhibitory effect on liver cancer stem cells Ibis, Kubra; Sinoplu, Esra; ÇALIŞKAN, BURCU; Kahraman, Deniz Cansen; Cetin-Atalay, Rengul; BANOĞLU, ERDEN (2021-10-01) In our effort for the development of novel anticancer therapeutics, a series of isoxazole-piperazine analogues were prepared, and primarily screened for their antiproliferative potential against hepatocellular carcinoma (H...
CROssBAR: comprehensive resource of biomedical relations with knowledge graph representations DOĞAN, TUNCA; Atas, Heval; Joshi, Vishal; Atakan, Ahmet; Rifaioglu, Ahmet Sureyya; Sinoplu, Esra; Nightingale, Andrew; Saidi, Rabie; Volynkin, Vladimir; Zellner, Hermann; Cetin-Atalay, Rengul; Martin, Maria; Atalay, Volkan (2021-09-01) Systemic analysis of available large-scale biological/biomedical data is critical for studying biological mechanisms, and developing novel and effective treatment approaches against diseases. However, different layers of t...

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