Alternative polyadenylation and RNA-binding proteins

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2016-08-01

Author

Erson Bensan, Ayşe Elif

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Our understanding of the extent of microRNA-based gene regulation has expanded in an impressive pace over the past decade. Now, we are beginning to better appreciate the role of 3'-UTR (untranslated region) cis-elements which harbor not only microRNA but also RNA-binding protein (RBP) binding sites that have significant effect on the stability and translational rate of mRNAs. To add further complexity, alternative polyadenylation (APA) emerges as a widespread mechanism to regulate gene expression by producing shorter or longer mRNA isoforms that differ in the length of their 3'-UTRs or even coding sequences. Resulting shorter mRNA isoforms generally lack cis-elements where trans-acting factors bind, and hence are differentially regulated compared with the longer isoforms. This review focuses on the RBPs involved in APA regulation and their action mechanisms on APA-generated isoforms. A better understanding of the complex interactions between APA and RBPs is promising for mechanistic and clinical implications including biomarker discovery and new therapeutic approaches.

Subject Keywords

Molecular Biology, Endocrinology

URI

https://hdl.handle.net/11511/34509

Journal

JOURNAL OF MOLECULAR ENDOCRINOLOGY

DOI

https://doi.org/10.1530/jme-16-0070

Collections

Department of Biology, Article

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Citation Formats

A. E. Erson Bensan, “Alternative polyadenylation and RNA-binding proteins,” JOURNAL OF MOLECULAR ENDOCRINOLOGY, pp. 0–0, 2016, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/34509.