Connections between CHFR, the cell cycle and chemosensitivity Are they critical in cancer?

Keller, Jennifer A.
Erson Bensan, Ayşe Elif
Petty, Elizabeth M.
Commentary to: Alternative efficacy-predicting markers for paclitaxel instead of CHFR in non-small cell lung cancer Masafumi Takeshita, Takaomi Koga, Koichi Takayama, Tokujiro Yano, Yoshihiko Maehara, Yoichi Nakanishi and Katsuo Sueishi


miRNAs and cancer New research developments and potential clinical applications
Erson Bensan, Ayşe Elif (Informa UK Limited, 2009-12-15)
miRNAs are small non-protein coding transcripts that regulate gene expression post-transcriptionally by binding to the 3' UTRs (untranslated regions) of messenger RNAs (mRNAs). The number of newly discovered miRNAs and our understanding of their biological roles continue to grow. In addition to their roles in important biological processes such as development, differentiation, proliferation and cell death, deregulated expression of miRNAs has been implicated in a wide range of pathologies, especially in can...
Identification of biomarkers associated with partial epithelial to mesenchymal transition in the secretome of slug over-expressing hepatocellular carcinoma cells
Karaosmanoglu, Oguzhan; Banerjee, Sreeparna; SİVAS, HÜLYA (Springer Science and Business Media LLC, 2018-08-01)
Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related deaths worldwide. Complete epithelial to mesenchymal transition (EMT) has long been considered as a crucial step for metastasis initiation. It has, however, become apparent that many carcinoma cells can metastasize without complete loss of epithelial traits or with incomplete gain of mesenchymal traits, i.e., partial EMT. Here, we aimed to determine the similarities and differences between complete and partial EMT through over-expr...
Significance of genetic Polymorphisms at multiple loci of CYP2E1 in the risk of development of childhood acute lymphoblastic leukemia
Ulusoy, Gulen; Adalı, Orhan; Tumer, Tugba Boyunegmez; Sahin, Gurses; Gozdasoglu, Sevgi; Arinc, Emel (S. Karger AG, 2007-01-01)
Background/Aims: The molecular etiology of childhood acute lymphoblastic leukemia (ALL) is likely to involve interactions between environmental factors and genetic make up. Understanding these interactions between various predisposing genes for the risk of developing childhood leukemia is of considerable importance. CYP2E1 is a susceptible gene in this respect, especially for its capacity to bioactivate many procarcinogens including benzene and N-nitrosodimethylamine. The CYP2E1 gene possesses several polym...
Monoclonal antibodies for targeted therapy in colorectal cancer.
Banerjee, Sreeparna (Informa UK Limited, 2010-04-15)
Traditional therapeutic regimens of solid tumors such as chemotherapy and radiotherapy often do not distinguish between malignant and normal tissues, resulting in considerable side-effects. Monoclonal antibodies (mAbs), targeted against antigens dysregulated in cancers, have therefore generated great interest in both clinical and research settings. The antibodies are either chimeric or human(ized) and can bind to and inhibit target proteins overexpressed in both solid tumors and hematological malignancies. ...
Tunable aryl alkyl ionic liquids (TAAILs) based on 1-aryl-3,5-dimethy1-1H-pyrazoles
Özdemir, Melek (Elsevier BV, 2017-12-01)
A series of fifteeen new 1-aryl-2,3,5-trimethylpyrazolium salts ([Ph(R)C(1)Pz][X], R: 4-Cl, 4-Br, 4-Me, 4-OMe, 4-NO2; methyl, X: methanesulfonate tetrafluoroborate [BF4-] and hexafluorophosphate [PF6-]) were synthesized and characterized. Thermal properties (Tm/T-g and Td) of all the salts were investigated, Five of the salts can be classed as ionic liquids since they are liquid at rate time or melt below 100 degrees C three of which are room temperature ionic liquids (RTILs). The influence of the substitue...
Citation Formats
J. A. Keller, A. E. Erson Bensan, and E. M. Petty, “Connections between CHFR, the cell cycle and chemosensitivity Are they critical in cancer?,” CANCER BIOLOGY & THERAPY, pp. 946–948, 2010, Accessed: 00, 2020. [Online]. Available: