Parametric continuous feed stream design to fine-tune fed-batch bioreactor performance: recombinant human growth hormone production in Bacillus subtilis

Date

2016-11-01

Author

ÇALIK GARCİA, GÜZİDE
KOCABAŞ, PINAR
Afsar, Hande
Çalık, Pınar
Ozdamar, Tuncer H.

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BACKGROUND: Design principles of a fed-batch bioreactor system to fine-tune bioreactor performance by increasing production and productivity are investigated. To enhance the production and productivity in fed-batch fermentation of recombinant human growth hormone (rhGH) by Bacillus subtilis, this work develops a continuous feed stream (CFS) design method with the parameters, cultivation time to switch batch-to fed-batch operation, so called transition time, t(T), and specific growth rate, mu.

Subject Keywords

Biotechnology, Fuel Technology, Inorganic Chemistry, Renewable Energy, Sustainability and the Environment, Organic Chemistry, Waste Management and Disposal, Pollution, General Chemical Engineering

URI

https://hdl.handle.net/11511/37865

Journal

JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY

DOI

https://doi.org/10.1002/jctb.4864

Collections

Department of Chemical Engineering, Article

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Citation Formats

G. ÇALIK GARCİA, P. KOCABAŞ, H. Afsar, P. Çalık, and T. H. Ozdamar, “Parametric continuous feed stream design to fine-tune fed-batch bioreactor performance: recombinant human growth hormone production in Bacillus subtilis,” JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY, pp. 2740–2750, 2016, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/37865.