m6A Modification and Implications for microRNAs.

Date

2017-01-01

Author

Erson Bensan, Ayşe Elif
BEGIK, O

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

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Objective: RNA is chemically modified with over 100 distinct reactions. Among these reactions, methylation is probably the most extensively studied modification on the RNA molecule. Studies suggest methylation of Adenine residues (m6A) to be widespread in the transcriptome with potentially important roles in biological processes. Method: Here, we review recent literature on m6A modification and potential implications for microRNA (miRNA) mediated gene expression regulation. These implications involve miRNA biogenesis, mRNA-miRNA interactions and m6A target selection. Conclusion: Understanding the extent and functions of m6A is likely to improve our understanding of the complexities of the transcriptome regulation in normal and in disease states.

Subject Keywords

Transcriptome, RNA methylation, mRNA, microRNA, m6A, 3’UTR

URI

https://hdl.handle.net/11511/38273

Collections

Department of Biology, Article