Gene expression becomes heterogeneous with age

Somel, Mehmet
Bahn, Sabine
Paabo, Svante
Lachmann, Michael


Cloning of chitinase a gene (chiA) from serratia marcescens Bn10 and its expression in coleoptera-specific bacillus thuringiensis
Okay, Sezer; Özcengiz, Gülay; Department of Biology (2005)
Chitinases have been shown to be potential agents for biological control of the plant diseases caused by various phytopathogenic fungi and insect pests, because fungal cell walls and insect exoskeletons contain chitin as a major structural component. Chitinase has also been found to increase the efficacy and potency of Bacillus thuringiensis crystal (Cry) proteins toxic to larvae of insect pests. The reason of this synergy is the presence of chitin in the structure of the outer membrane of larval midgut. In...
Proteome-wide analysis of the functional roles of Bacilysin biosynthesis in Bacillus subtilis
Taşkın Aras, Aslı; Özcengiz, Gülay; Department of Biology (2010)
The members of the genus Bacillus produce a wide variety of secondary metabolites with antimetabolic and pharmacological activities. Most of these metabolites are small peptides that have unusual components and chemical bonds and synthesized nonribosomally by multifunctional enzyme complexes called peptide synthetases. Bacilysin, being produced and excreted by certain strains of Bacillus subtilis, is one of the simplest peptide antibiotics known. It is a dipeptide with an N-terminal L-alanine and an unusual...
Targeted disruption of homoserine dehydrogenase gene in Streptomyces clavuligerus and its effects on cephamycin C production
Çaydaşı (Koca), Ayşe; Özcengiz, Gülay; Department of Biology (2006)
The members of the genus Streptomyces are well-known for their capacity to synthesize a vast repertoire of secondary metabolites, including many useful antibiotics and proteins. Streptomyces clavuligerus is the producer of the medically important β-lactam antibiotics such as cephamycin C and the potent β-lactamase inhibitor clavulanic acid. The aspartate pathway of S. clavuligerus is an important primary metabolic pathway providing substrates for β-lactam synthesis. This pathway uses L-aspartic acid as the ...
Characterisation of local isolates of Enterobacteriaceae from Turkey
İçgen, Bülent; Gültekin, Güzin Candan; Özcengiz, Gülay (Elsevier BV, 2002-01-01)
20 local isolates of enterics belonging to the genera Salmonella, Enterobacter Proteus, Citrobacter from human, chicken and/or egg were characterised for their antibiotic resistance patterns, plasmid profiles, phage types, outer membrane proteins, and lipopolysaccharide patterns. Relatedness of these characteristics for epidemiological analysis was assessed. 18 (90%) strains were resistant to at least one antibiotic and those (multi-drug resistant ones) resisting to two or more antibiotics constituted 50% o...
Gene expression profiling of Thermoplasma volcanium under extreme stress conditions
Zabci, Sema; Kocabıyık, Semra (2014-07-01)
Citation Formats
M. Somel, S. Bahn, S. Paabo, and M. Lachmann, “Gene expression becomes heterogeneous with age,” CURRENT BIOLOGY, pp. 0–0, 2006, Accessed: 00, 2020. [Online]. Available: