Azacyanines as Novel Topoisomerase II Alpha Inhibitors

Date

2020-01-01

Author

Guloglu, Sercan
Kirmaci, Fahriye Nur
Persil Çetinkol, Özgül
Forough, Mehrdad
Gulkaya, Aybuke

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Introduction: Topoisomerase II alpha (Topo II alpha) has become one of the extensively exploited targets in chemotherapy due to its role in regulating the topological constraints of DNA during replication and transcription. Small molecules targeting Topo II alpha's activity such as etoposide (VP-16) and doxorubicin are extensively used in the treatment of many different types of cancer.

Subject Keywords

Molecular Medicine, Drug Discovery, Pharmaceutical Science

URI

https://hdl.handle.net/11511/40370

Journal

LETTERS IN DRUG DESIGN & DISCOVERY

DOI

https://doi.org/10.2174/1570180816666190628161945

Collections

Department of Chemistry, Article

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Citation Formats

S. Guloglu, F. N. Kirmaci, Ö. Persil Çetinkol, M. Forough, and A. Gulkaya, “Azacyanines as Novel Topoisomerase II Alpha Inhibitors,” LETTERS IN DRUG DESIGN & DISCOVERY, pp. 666–671, 2020, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/40370.