A Highly Active Catalyst for Huisgen 1,3-Dipolar Cycloadditions Based on the Tris(triazolyl)methanol-Cu(I) Structure

Date

2009-10-15

Author

Özçubukçu, Salih
JİMENO, Ciril
Pericas, Miquel A.

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A new tris(1-benzyl-1H-1,2,3-triazol-4-yl)methanol ligand 3 has been prepared by a triple Cu(I)-catalyzed alkyne-azide 1,3-dipolar cycloaddition (CuAAC). Ligand 3 forms a stable complex with CuCl, which catalyzes the Huisgen 1,3-dipolar cycloaddition on water or under neat conditions. Low catalyst loadings, short reaction times at room temperature, and compatibility with free amino groups make 3-CuCl an outstanding catalyst for CuAAC.

Subject Keywords

Physical and Theoretical Chemistry, Organic Chemistry, Biochemistry

URI

https://hdl.handle.net/11511/40921

Journal

ORGANIC LETTERS

DOI

https://doi.org/10.1021/ol9018776

Collections

Department of Chemistry, Article

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Citation Formats

S. Özçubukçu, C. JİMENO, and M. A. Pericas, “A Highly Active Catalyst for Huisgen 1,3-Dipolar Cycloadditions Based on the Tris(triazolyl)methanol-Cu(I) Structure,” ORGANIC LETTERS, pp. 4680–4683, 2009, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/40921.