Solution-phase mixture synthesis with double-separation tagging: Double demixing of a single mixture provides a stereoisomer library of 16 individual murisolins

Date

2005-01-01

Author

WİLCOX, CRAİG STEPHEN
Gudipati, V
Lu, HJ
Türkyılmaz, Serhan
Curran, DP

Metadata

Show full item record

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Item Usage Stats

68
views

0
downloads

Two tags are better than one: Sixteen individual stereoisomers of murisolin (see scheme) are synthesized together and isolated in pure form with the aid of a double‐separation tagging procedure. A strategy for solution‐phase stereoisomer synthesis based on double‐separation tagging and double demixing is implemented with fluoroalkyl and oligoethylene glycol (OEG, (OCH2CH2)nOCH3) tags.

Subject Keywords

General Chemistry, Catalysis

URI

https://hdl.handle.net/11511/41195

Journal

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

DOI

https://doi.org/10.1002/anie.200501989

Collections

Department of Chemistry, Article

Suggestions

OpenMETU
Core

Temperature- and Voltage-Induced Ligand Rearrangement of a Dynamic Electroluminescent Metallopolymer Asil Alptekin, Demet; Patra, Asit; de Hatten, Xavier; del Barrio, Jesus; Scherman, Oren A.; Nitschke, Jonathan R.; Friend, Richard H. (Wiley, 2014-08-04) A dynamic-covalent metal-containing polymer was synthesized by the condensation of linear diamine and dialdehyde subcomponents around copper(I) templates in the presence of bidentate phosphine ligands. In solution, the red polymers undergo a sol-gel transition upon heating to form a yellow gel, a process that can be either reversible or irreversible depending on the solvent used. When fabricated into a light-emitting electrochemical cell (LEC), the polymer emits infrared light at low voltage. As the voltage...
2,1,3-Benzooxadiazole, thiophene and benzodithiophene based random copolymers for organic photovoltaics: thiophene versus thieno[3,2-b]thiophene as pi-conjugated linkers Goker, SEZA; HIZALAN, Gonul; AKTAS, Ece; KUTKAN, Seda; Çırpan, Ali; Toppare, Levent Kamil (Royal Society of Chemistry (RSC), 2016-12-01) Three conjugated random copolymers comprising benzodithiophene and thiophene as the donor units and benzooxadiazole as the acceptor unit, spaced with thiophene and thieno[3,2-b]thiophene pi-bridges, were designed and synthesized. The effects of different linkers on the optical and electrochemical properties were investigated. The polymer containing a thieno[3,2-b]thiophene pi-bridge revealed a red shifted absorption compared to its thiophene analogue. Morphological and photovoltaic properties of a polymer:f...
INTRAZEOLITE NONSTOICHIOMETRIC TUNGSTEN-OXIDES N[WO3-X]-NA56Y(0-LESS-THAN-N-LESS-THAN-OR-EQUAL-TO-32, 0-LESS-THAN-OR-EQUAL-TO-X-LESS-THAN-OR-EQUAL-TO-1) OZIN, GA; PROKOPOWICZ, RA; Özkar, Saim (American Chemical Society (ACS), 1992-11-01) The photooxidation of alpha-cage encapsulated n[W(CO)6]-Na56Y, where 0 hv n[WO3]-Na56Y + 6nCO2 Following photooxidation, half of the alpha-cage void volume in the Na56Y host is freed so that subsequent precursor (saturation level) impregnations/photooxidations can be carried out in a stepwise fashion, proceeding as n = 16, 24, 28, 30, ..., 32 per unit cell. Thermal vacuum treatment of these materials proceeds in two well-defined steps around 300 and 400-degrees-C to yield encapsulated n[WO3-x]-Na56Y materi...
Assembly of an antiparallel homo-adenine DNA duplex by small-molecule binding Persil Çetinkol, Özgül; JAIN, SS; HUD, NV (American Chemical Society (ACS), 2004-07-21) Molecules that reversibly bind DNA and trigger the formation of non-Watson−Crick secondary structures would be useful in the design of dynamic DNA nanostructures and as potential leads for new therapeutic agents. We demonstrate that coralyne, a small crescent-shaped molecule, promotes the formation of a duplex secondary structure from homo-adenine oligonucleotides. AFM studies reveal that the staggered alignment of homo-adenine oligonucleotides upon coralyne binding produces polymers of micrometers in lengt...
ROMP-polymers, in asymmetric catalysis: The role of the polymer backbone Bolm, C; Tanyeli, Cihangir; Grenz, A; Dinter, CL (Wiley, 2002-08-01) Ring-opening metathesis polymerization (ROMP) is utilized for the synthesis of highly functionalized polymers with covalently bound chiral prolinol units. The linear macromolecules act as multifunctional ligands in homogeneous asymmetric catalysis. The solubility of the polymers and their catalytic performance can be tuned by random copolymerization with achiral units in a simple and flexible manner. Use of norbornenes with additional well-defined stereogenic centers in the polymerizable core of the monomer...

Citation Formats

C. S. WİLCOX, V. Gudipati, H. Lu, S. Türkyılmaz, and D. Curran, “Solution-phase mixture synthesis with double-separation tagging: Double demixing of a single mixture provides a stereoisomer library of 16 individual murisolins,” ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, pp. 6938–6940, 2005, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/41195.