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Solution-phase mixture synthesis with double-separation tagging: Double demixing of a single mixture provides a stereoisomer library of 16 individual murisolins

Gudipati, V
Lu, HJ
Türkyılmaz, Serhan
Curran, DP
Two tags are better than one: Sixteen individual stereoisomers of murisolin (see scheme) are synthesized together and isolated in pure form with the aid of a double‐separation tagging procedure. A strategy for solution‐phase stereoisomer synthesis based on double‐separation tagging and double demixing is implemented with fluoroalkyl and oligoethylene glycol (OEG, (OCH2CH2)nOCH3) tags.