Accelerated aging-related transcriptome changes in the female prefrontal cortex

Download

index.pdf

Date

2012-10-01

Author

Yuan, Yuan
Chen, Yi-Ping Phoebe
Boyd-Kirkup, Jerome
Khaitovich, Philipp
Somel, Mehmet

Metadata

Show full item record

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Item Usage Stats

55
views

38
downloads

Human female life expectancy is higher than that of males. Intriguingly, it has been reported that women display faster rates of age-related cognitive decline and a higher prevalence of Alzheimers disease (AD). To assess the molecular bases of these contradictory trends, we analyzed differences in expression changes with age between adult males and females, in four brain regions. In the superior frontal gyrus (SFG), a part of the prefrontal cortex, we observed manifest differences between the two sexes in the timing of age-related changes, that is, sexual heterochrony. Intriguingly, age-related expression changes predominantly occurred earlier, or at a faster pace, in females compared to men. These changes included decreased energy production and neural function and up-regulation of the immune response, all major features of brain aging. Furthermore, we found that accelerated expression changes in the female SFG correlated with expression changes observed in AD, as well as stress effects in the frontal cortex. Accelerated aging-related changes in the female SFG transcriptome may provide a link between a higher stress exposure or sensitivity in women and the higher prevalence of AD.

Subject Keywords

Sex difference, Prefrontal cortex, Gene expression, Central nervous system, Alzheimer's disease

URI

https://hdl.handle.net/11511/46753

Journal

AGING CELL

DOI

https://doi.org/10.1111/j.1474-9726.2012.00859.x

Collections

Department of Biology, Article

Suggestions

OpenMETU
Core

Notable decrease in transcriptome conservation during mammalian aging Turan, Zeliha Gözde; Somel, Mehmet; Department of Biology (2016) Aging is a complex process that causes decline in organisms’ reproductive capacity and chance of survival. Even though aging tends to reduce fitness, it is not eliminated by natural selection and is observed in many multicellular species, and this leads to an evolutionary paradox. The mutation accumulation theory states that due to the declining force of natural selection with age, old-age-expressed deleterious mutations will not be effectively eliminated, and can contribute to the aging phenotype. A limite...
Longitudinal models for life expectancy at birth in Turkey Asker, Özlem; İlk Dağ, Özlem; Department of Statistics (2021-1-15) World Health Organization (WHO) gives the definition of life expectancy at birth as ―the average number of years that a newborn is expected to live if current mortality rates continue to apply‖. Life expectancy at birth is an important indicator of a country's overall health status and its economic and social level of development. In order for governments to set their policies correctly, it is important to determine factors that affect life expectancy at birth and how they affect it. In this thesis, longitu...
Convergent evolution of primate testis transcriptomes in response to mating strategy differences Yapar, Etka; Somel, Mehmet; Department of Biology (2021-2-01) In independent mammalian lineages where females mate with multiple males (multimale mating strategies), males have evolved larger testicles relative to those lineages where females mate with fewer males (single-male mating strategies). This convergent evolution of relative testis size is attributed to the sexual selection acting as the immense sperm competition between males of multi-male mating lineages. Here I analyze bulk testis transcriptomes of humans, chimpanzees, gorillas, rhesus macaques, mice and r...
Investigation of drug-related changes on bone tissues of rat animal models in healthy and disease states Garip, Şebnem; Severcan, Feride; Banerjee, Sreeparna; Department of Biochemistry (2012) Disease- and drug-related bone disorders are rapidly increasing in the population. The drugs which are used for the treatment of neurodegenerative diseases and metabolic derangements, may have negative or positive effects on bone tissues. In the first study, the possible side-effects of Carbamazepine and epileptic seizures on bone structure and composition were investigated by FTIR and synchrotron-FTIR microspectroscopy, AFM and micro- and nano-hardness analysis. The effects on the blood parameters, bone tu...
Can rhBMP-2 Containing Collagen Sponges Enhance Bone Repair in Ovariectomized Rats?: A Preliminary Study Sarban, Sezgin; Senkoylu, Alparslan; Isikan, U. Erdem; KORKUSUZ, PETEK; Korkusuz, Feza (Ovid Technologies (Wolters Kluwer Health), 2009-12-01) With an aging population the frequency of postmenopausal fractures is increasing. Methods to enhance the repair of osteoporotic bone repair therefore become more important to reduce the society burden of care. We asked if absorbable collagen sponges containing recombinant human bone morphogenetic protein-2 (rhBMP-2) have the potential to enhance bone repair. We randomly assigned 40 rats into the ovariectomy and sham operation groups. A segmental defect was created in the right tibia 12 weeks after ovariecto...

Citation Formats

Y. Yuan, Y.-P. P. Chen, J. Boyd-Kirkup, P. Khaitovich, and M. Somel, “Accelerated aging-related transcriptome changes in the female prefrontal cortex,” AGING CELL, pp. 894–901, 2012, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/46753.