Quantitative analysis of biofluid spots by coated blade spray mass spectrometry, a new approach to rapid screening

Date

2017-11-23

Author

Gomez-Rios, German Augusto
Tascon, Marcos
Reyes-Garces, Nathaly
Boyacı, Ezel
Poole, Justen
Pawliszyn, Janusz

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

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This study demonstrates the quantitative capabilities of coated blade spray (CBS) mass spectrometry (MS) for the concomitant analysis of multiple target substances in biofluid spots. In CBS-MS the analytes present in a given sample are first isolated and enriched in the thin coating of the CBS device. After a quick rinsing of the blade surface, as to remove remaining matrix, the analytes are quickly desorbed with the help of a solvent and then directly electrosprayed into the MS analyzer. Diverse pain management drugs, controlled substances, and therapeutic medications were successfully determined using only 10 mu L of biofluid, with limits of quantitation in the low/sub ng.mL(-1) level attained within 7 minutes.

Subject Keywords

Solid-phase Microextraction, Dried blood spots, Lc-Ms/Ms Bıoanalysıs, Paper Spray;, Complex Matrices, Real-Time, Ionization, Samples, Extraction

URI

https://hdl.handle.net/11511/48580

Collections

Department of Chemistry, Article