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Quantitative analysis of biofluid spots by coated blade spray mass spectrometry, a new approach to rapid screening
Date
2017-11-23
Author
Gomez-Rios, German Augusto
Tascon, Marcos
Reyes-Garces, Nathaly
Boyacı, Ezel
Poole, Justen
Pawliszyn, Janusz
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This work is licensed under a
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
.
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This study demonstrates the quantitative capabilities of coated blade spray (CBS) mass spectrometry (MS) for the concomitant analysis of multiple target substances in biofluid spots. In CBS-MS the analytes present in a given sample are first isolated and enriched in the thin coating of the CBS device. After a quick rinsing of the blade surface, as to remove remaining matrix, the analytes are quickly desorbed with the help of a solvent and then directly electrosprayed into the MS analyzer. Diverse pain management drugs, controlled substances, and therapeutic medications were successfully determined using only 10 mu L of biofluid, with limits of quantitation in the low/sub ng.mL(-1) level attained within 7 minutes.
Subject Keywords
Solid-phase Microextraction
,
Dried blood spots
,
Lc-Ms/Ms Bıoanalysıs
,
Paper Spray;
,
Complex Matrices
,
Real-Time
,
Ionization
,
Samples
,
Extraction
URI
https://hdl.handle.net/11511/48580
Journal
SCIENTIFIC REPORTS
DOI
https://doi.org/10.1038/s41598-017-16494-z
Collections
Department of Chemistry, Article