Epilobium hirsutum alters xenobiotic metabolizing CYP1A1, CYP2E1, NQO1 and GPx activities, mRNA and protein levels in rats

Date

2013-05-01

Author

Karakurt, Serdar
SEMİZ, ASLI
Celik, Gurbet
GENÇLER ÖZKAN, AYŞE MİNE
ŞEN, ALAATTİN
Adalı, Orhan

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Context: Natural products have attracted increasing interests due to their use in flavoring, nutrition, cosmetics, pharmacy and medicine. Epilobium hirsutum L. (Onagraceae) is known for its analgesic, antimicrobial, and antiproliferative activity. CYP1A1 and CYP2E1, xenobiotic metabolizing enzymes, serve as a metabolic activation route yielding reactive metabolites that are eliminated by the action of NQO1 and glutathione peroxidase (GPx) enzymes.

Subject Keywords

Complementary and alternative medicine, Molecular Medicine, Pharmacology, Drug Discovery, Pharmaceutical Science, General Medicine

URI

https://hdl.handle.net/11511/48791

Journal

PHARMACEUTICAL BIOLOGY

DOI

https://doi.org/10.3109/13880209.2012.762404

Collections

Department of Biology, Article

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Citation Formats

S. Karakurt, A. SEMİZ, G. Celik, A. M. GENÇLER ÖZKAN, A. ŞEN, and O. Adalı, “Epilobium hirsutum alters xenobiotic metabolizing CYP1A1, CYP2E1, NQO1 and GPx activities, mRNA and protein levels in rats,” PHARMACEUTICAL BIOLOGY, pp. 650–658, 2013, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/48791.