İlaç dirençli meme kanseri hücre hatlarında protein kinaz D2 ifadesinin dirençliliğe etki mekanizmalarının incelenmesi

Differential gene expression analysis in drug resistant multiple myeloma cell lines Mutlu, Pelin; Gündüz, Ufuk; Department of Biology (2009) The emergence of drug-resistance of tumor cells is a major complication for succesful chemotherapy. In this study, the molecular mechanisms of resistance to prednisone, vincristine and melphalan in multiple myeloma cell lines, RPMI-8226 and U-266 were investigated. Drug resistance was induced by application of the drugs by stepwise dose increments and confirmed by XTT cytotoxicity assay. Gene expression analysis demostrated that MDR1 gene is one of the most important factor causing the multidrug resistance ...
Characterization of liposomal celecoxib formulation as a drug delivery system in colorectal cancer cell lines Erdoğ, Aslı; Banerjee, Sreeparna; Department of Biotechnology (2012) Colorectal carcinoma (CRC) is one of the most common cancers and is the leading cause of cancer deaths in much of the developed world. Owing to the high incidence of drug resistance and potential toxic effects of chemotherapy drugs, much research is currently underway to design better strategies for smart drug delivery systems. Cyclooxygenase-2 (COX-2) pathway is associated with poor prognosis in colon carcinomas. The selective COX-2 inhibitor drug Celecoxib (CLX) has been shown to posses COX-2 independent ...
Isolation, molecular characterization of food-borne drug resistant salmonella spp. and detection of class 1 integrons Avşaroğlu, M. Dilek; Bozoğlu, Faruk; Department of Biotechnology (2007) In this study, 59 epidemiologically unrelated Salmonella strains isolated from foods in Türkiye and 49 Salmonella strains obtained from National Salmonella Reference Laboratories of Germany were analysed. For the characterization of strains, analyses such as serotyping, phage typing, antibiotyping and molecular biological characterization were done. The strains exhibited 17 different serotypes with S. Enteritidis serotype and PT21 phage type being the most prevalent in Turkish isolates. The highest antimicr...
Deep learning for prediction of drug-target interaction space and protein functions Rifaioğlu, Ahmet Süreyya; Atalay, Mehmet Volkan; Department of Computer Engineering (2020) With the advancement of sequencing and high-throughput screening technologies, large amount of sequence and compound data have been accumulated in biological and chemical databases. However, only small number of proteins and compounds have been annotated by wet-lab experiments due to the huge compound and chemical space. Therefore, computational methods have been developed to annotate protein and compound space. In this thesis, we describe the design and implementation of several methods for accurate drug-t...
Investigation of the drug resistance in capecitabine resistant hct-116, dabrafenib resistant ht-29, and sn-38 resistant ht-29 cell lines using cellular barcoding technology Baygın, Rana Can; Acar, Ahmet; Department of Biology (2022-11-3) Cancer is a complex disease, and understanding its biology holds great importance. Tumor cells exhibit hallmarks of cancer, including aberrantly activated signaling pathways and gain or loss genomic alterations that result in alterations in their differentiation programs, survival, proliferation, and programmed cell death. Developing resistance to therapeutic agents is one of the major problems in cancer therapies. Exploiting drug resistance using the principles of clonal evolution can pave the way to overc...

Citation Formats

Y. S. Azarkan and U. Gündüz, “İlaç dirençli meme kanseri hücre hatlarında protein kinaz D2 ifadesinin dirençliliğe etki mekanizmalarının incelenmesi,” 2014. Accessed: 00, 2020. [Online]. Available: https://app.trdizin.gov.tr/publication/project/detail/TVRNMk1URXg.