Remarkable phosphodiester hydrolysis activity of a novel Ce-IV complex in neutral aqueous solutions

Date

1999-09-08

Author

Baykal, U
Akkaya, Mahinur
Akkaya, EU

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A novel Ce-IV-complex of 1,4,7-tris(carbamoylmethyl)-1,4,7-triazacyclononane has been synthesized. The complex is both stable in aqueous solutions at neutral pH and very efficient in promoting the hydrolysis of a phosphodiester model compound and yeast tRNA(phe). The RNA model compound, 2-hydroxypropyl-p-nitrophenylphosphate hydrolysis is accelerated 7400-fold at pH 7.5, as a result of an unprecedented hydrolytic activity.

Subject Keywords

Phosphodiester hydrolysis, Artificial enzymes, Lanthanide complexes, RNA cleavage

URI

https://hdl.handle.net/11511/51793

Journal

JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL

DOI

https://doi.org/10.1016/s1381-1169(99)00160-0

Collections

Graduate School of Natural and Applied Sciences, Article

Citation Formats

U. Baykal, M. Akkaya, and E. Akkaya, “Remarkable phosphodiester hydrolysis activity of a novel Ce-IV complex in neutral aqueous solutions,” JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL, vol. 145, pp. 309–312, 1999, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/51793.