Remarkable phosphodiester hydrolysis activity of a novel Ce-IV complex in neutral aqueous solutions

Date

1999-09-08

Author

Baykal, U
Akkaya, Mahinur
Akkaya, EU

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A novel Ce-IV-complex of 1,4,7-tris(carbamoylmethyl)-1,4,7-triazacyclononane has been synthesized. The complex is both stable in aqueous solutions at neutral pH and very efficient in promoting the hydrolysis of a phosphodiester model compound and yeast tRNA(phe). The RNA model compound, 2-hydroxypropyl-p-nitrophenylphosphate hydrolysis is accelerated 7400-fold at pH 7.5, as a result of an unprecedented hydrolytic activity.

Subject Keywords

Phosphodiester hydrolysis, Artificial enzymes, Lanthanide complexes, RNA cleavage

URI

https://hdl.handle.net/11511/51793

Collections

Graduate School of Natural and Applied Sciences, Article