Drug resistant MCF-7 cells possessed epithelial-mesenchymal transition related gene expression pattern

Date

2009-07-01

Author

Iseri, O. D.
Kars, M. Demirel
Arpaci, F.
Atalay, C.
Pak, I.
Gündüz, Ufuk

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https://hdl.handle.net/11511/53104

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Drug resistant MCF-7 cells exhibit epithelial-mesenchymal transition gene expression pattern Iseri, Ozlem Darcansoy; Kars, Meltem Demirel; Arpaci, Fikret; Atalay, Can; Pak, Isin; Gündüz, Ufuk (2011-02-01) Purpose: Multidrug resistance is resistance to structurally unrelated anticancer agents. Large-scale expression analysis by using high-density oligonucleotide microarrays may provide information about new candidate genes contributing to MDR. This study demonstrates alterations in expression levels of several genes related to epithelial-mesenchymal transition (EMT) in paclitaxel, docetaxel, and doxorubicin resistant MCF-7 cells.
Drug Resistant MCF-7 Cells have Altered Expression Levels of beta-Tubulin Isotypes and Mutations in TUBB Gene Iseri, Ozlem D.; Kars, Meltem D.; Gündüz, Ufuk (2010-06-01) Antimicrotubule agents paclitaxel, docetaxel and vincristine are used in treatment of breast cancer. They bind to beta-tubulin subunit of microtubules. Multidrug resistance developed against these drugs remains a serious clinical problem. Different beta-tubulin izotypes possess differential assembly/disassembly dynamics. In this study, expressions of beta-tubulin isotypes, and mutations in TUBE gene were investigated in paclitaxel, docetaxel and vincristine resistant MCF-7 breast carcinoma cell lines. Resis...
Drug Resistant MCF-7 Cell Lines Also Developed Cross-Resistance to Structurally Unrelated Anticancer Agents Iseri, Ozlem D.; Kars, Meltem D.; Eroglu, Seckin; Gündüz, Ufuk (2009-03-01) The cells developing resistance to an applied drug may also present cross-resistance to other anticancer drugs which are not applied. In this study, the development of cross-resistance in paclitaxel (MCF-7/Pac), docetaxel (MCF-7/Doc), vincristine (MCF-7/Vinc) and doxorubicin (MCF-7/Dox) resistant MCF-7 cells to selective anticancer drugs, tamoxifen and all trans-retinoic acid (ATRA) were investigated. Combined antiproliferative effects of these drugs in different combinations were also evaluated by checkerb...
Drug resistant breast cancer cells overexpress ETS1 gene Kars, Meltem Demirel; Iseri, Ozlem Darcansoy; Gündüz, Ufuk (2010-09-01) Purpose. - Multidrug resistance (MDR) is resistance to wide range of structurally unrelated anticancer agents. MDR is a serious limitation to the effective chemotherapy. Involvement of ETS1 overexpression in upregulation of MDR1 gene expression is implicated. In the present study the aim was to assess the involvement of ETS1 and the genes, which encode the proteins interacting with ETS1 in drug resistant MCF-7 breast cancer cells.
Drug metabolism and apoptosis in HEPG2 cell line Rustam, Samir; Güray, Tülin; İrtem Kartal, Deniz; Department of Biology (2017) The liver is the principal site of drug metabolism. Drugs and other chemicals are all metabolized in the liver through the drug-metabolizing enzyme system. Metabolized drugs can have an effect on one another through crosstalk between drug metabolism pathways. Herbs used in folk and mainstream medicine, when taken together with drugs, can affect the rate at which drugs are processed by the liver. Salvia species are one of many herbal remedies which can be used together with prescribed drugs as part of altern...

Citation Formats

O. D. Iseri, M. D. Kars, F. Arpaci, C. Atalay, I. Pak, and U. Gündüz, “Drug resistant MCF-7 cells possessed epithelial-mesenchymal transition related gene expression pattern,” 2009, vol. 276, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/53104.