Coumarin 7-hydroxylation (CYP2A6) polymorphism in a Turkish population

Selenium alters the lipid content and protein profile of rat heart: An FTIR micro spectroscopic study Toyran, Neslihan; Turan, Belma; Severcan, Feride (Elsevier BV, 2007-02-15) Cardiovascular disease is one of the most important causes of morbidity and mortality in Western countries. In addition, it is well documented that selenium (Se) deficiency has been linked to cardiovascular diseases. This study was undertaken to present the effect of sodium selenite on left and right myocardia, and small veins of normal control rat heart at molecular level by using Fourier transform infrared (FTIR) microspectroscopy. The results mainly reveal that, Se treatment causes an increase in lipid c...
Celecoxib reduces fluidity and decreases metastatic potential of colon cancer cell lines irrespective of COX-2 expression Sade, Asli; Tuncay, Seda; Cimen, Ismail; Severcan, Feride; Banerjee, Sreeparna (Portland Press Ltd., 2012-02-01) CLX (celecoxib), a selective COX-2 (cyclo-oxygenase-2) inhibitor, has numerous pleiotropic effects on the body that may be independent of its COX-2 inhibitory activity. The cancer chemopreventive ability of CLX, particularly in CRC (colorectal cancer), has been shown in epidemiological studies. Here we have, for the first time, examined the biophysical effects of CLX on the cellular membranes of COX-2 expressing (HT29) and COX-2 non-expressing (SW620) cell lines using ATR-FTIR (attenuated total reflectance ...
Inositol phospholipids activate plasma membrane ATPase in plants Memon, Abdul Razaque; Chen, Qiuyun; Boss, Wendy F. (Elsevier BV, 1989-8) Phosphatidylinositol-4-monophosphate and phosphatidylinositol-4,5-bisphosphate increased the activity of the vanadate-sensitive ATPase associated with plasma membranes isolated from both sunflower hypocotyls and carrot suspension culture cells. The response was not due to the metabolism of the polyphosphoinositides since diacylglycerol, inositol-1,4-bisphosphate, inositol-1,4,5-trisphosphate, glycerophosphoinositol monophosphate and glycerophosphoinositol bisphosphate had no effect. These data suggest that ...
Phanerochaete chrysosporium soluble proteome as a prelude for the analysis of heavy metal stress response Ozcan, Servet; Yildirim, Volkan; Kaya, Levent; Albrecht, Dirk; Becher, Doerte; Hecker, Michael; Özcengiz, Gülay (Wiley, 2007-04-01) A 2-D reference map in pI range 3-10 was constructed for the soluble protein fraction of Phancrochaete chrysosporium growing vegetatively under standard conditions. Functional annotation could be made for 517 spots out of 720 that were subjected to MALDI-TOF-MS analysis, according to the specific accession numbers from the P. chrysosporium genomic database. Further analysis of the data revealed 314 distinct ORFs, 118 of which yielded multiple spots on the master gel. Functional classification of the protein...
Structural and functional characterization of simvastatin-induced myotoxicity in different skeletal muscles Ozek, Nihal Simsek; Bal, I. Burak; SARA, MEHMET YILDIRIM; Onur, Rustu; Severcan, Feride (Elsevier BV, 2014-01-01) Background: Statins are the most commonly used drugs for the treatment of hypercholesterolemia. Their most frequent side effect is myotoxicity. To date, it remains unclear whether statins preferentially induce myotoxicity in fast- or in slow-twitch muscles. Therefore, we investigated these effects on fast- (extensor digitorum longus; EDL), slow- (soleus; SOL), and mixed-twitch muscles (diaphragm; DIA) in rats by comparing their contractile and molecular structural properties.

Citation Formats

M. ISCAN, H. ROSTAMI, M. ISCAN, N. T. Güray, A. RAUTIO, and O. PELKONEN, “Coumarin 7-hydroxylation (CYP2A6) polymorphism in a Turkish population ,” 1994, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/54916.