A NEW THIADIAZINE DERIVATIVE INDUCES OXIDATIVE STRESS DEPENDENT CELL DEATH IN HEPATOCELLULAR CARCINOMA STEM CELLS

Date

2019-10-01

Author

Kahraman, Deniz Cansen
Aytac, Peri
TOZKOPARAN KÖPRÜCÜ, BİRSEN
Atalay, Rengül

Metadata

Show full item record

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Item Usage Stats

137
views

0
downloads

URI

https://hdl.handle.net/11511/55101

Collections

Graduate School of Informatics, Conference / Seminar

Suggestions

OpenMETU
Core

A new thiadiazine derivative induces oxidative stress dependent JNK pathway activation and cell death in hepatocellular carcinoma Kahraman, Deniz Cansen; TOZKOPARAN KÖPRÜCÜ, BİRSEN; Atalay, Rengül (2019-07-01) Hepatocellular carcinoma (HCC) is the fifth most common and the second lethal cancer worldwide. HCC is resistant to conventional chemotherapy and radiotherapy due to its highly heterogenous structure. Therefore, it is crucial to design and develop novel therapeutic strategies against HCC. Non-steroidal anti-inflammatory drugs (NSAIDs) have long been studied for the treatment of acute and chronic conditions with pain and inflammation. In recent years, evidence from various studies suggested that NSAIDs reduc...
A new triazolothiadiazine derivative inhibits stemness and induces cell death in HCC by oxidative stress dependent JNK pathway activation Kahraman, Deniz Cansen; Guven, Ebru Bilget; Aytac, Peri S.; Aykut, Gamze; Tozkoparan, Birsen; Atalay, Rengul Cetin (2022-09-01) Hepatocellular carcinoma (HCC) is a highly heterogeneous cancer, and resistant to both conventional and targeted chemotherapy. Recently, nonsteroidal anti-inflammatory drugs (NSAIDs) have been shown to decrease the incidence and mortality of different types of cancers. Here, we investigated the cellular bioactivities of a series of triazolothiadiazine derivatives on HCC, which have been previously reported as potent analgesic/anti-inflammatory compounds. From the initially tested 32 triazolothiadiazine NSAI...
A highly substituted and fluorescent aromatic-fused imidazole derivative that shows enhanced antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) Bulut, Onur; Öktem, Hüseyin Avni; Yilmaz, M. Deniz (Elsevier BV, 2020-11-01) A novel highly substituted and fluorescent aromatic-fused imidazole derivative has been synthesized by rational design. This novel fluorescent material acts as an alternative antibacterial agent against Gram positive bacteria strains. It shows superior antibacterial activity (with MIC value of 8 mu g/mL) against methicillin-resistant Staphylococcus aureus (MRSA) when compared with standard antibiotic drugs Ampicillin (with MIC value of 128 mu g/mL) and Kanamycin (with MIC value of > 512 mu g/mL). The intera...
A new ZTL-type F-box functions as a positive regulator in disease resistance: VIGS analysis in barley against powdery mildew Dagdas, Yasin Fatih; Dagdas, Gulay; Unver, Turgay; Akkaya, Mahinur (2009-01-01) In our previous studies, we found a new Zeitlupe (ZTL) type F-box protein which is expressed at a higher level upon avirulent pathogen infection (Bozkurt et al., 2007). F-box proteins mark the proteins to be degraded through 26S proteasome system by ubiquitination. Since the information on the role of ubiquitin mediated proteolysis in disease responses is advancing rapidly, we sought to understand the way which F-box functions in resistance response as part of ubiquitin-proteasome pathway. Interestingly, in...
A Quinoxaline Derivative as a Long Wavelength Photosensitizer for Diaryliodonium Salts Bulut, Umut; Günbaş, Emrullah Görkem; Toppare, Levent Kamil (Wiley, 2010-01-01) This article reports the use of a quinoxaline derivative as a photosensitizer for diaryliodonium salt photoinitiators. 2,3-bis(3,4-bis(decyloxy)phenyl)-5,8-bis(2,3-dihydrothieno[3,4-b][1,4]-dioxin-5-yl)quinoxaline (DOPEQ), is a highly conjugated compound with strong absorption bands at wavelengths ranging from 300 to 550 nm and is shown to facilitate photoinitiated cationic polymerization of heterocyclic monomers such as oxiranes and oxetanes. The polymerizations are initiated at room temperature by using l...

Citation Formats

D. C. Kahraman, P. Aytac, B. TOZKOPARAN KÖPRÜCÜ, and R. Atalay, “A NEW THIADIAZINE DERIVATIVE INDUCES OXIDATIVE STRESS DEPENDENT CELL DEATH IN HEPATOCELLULAR CARCINOMA STEM CELLS,” 2019, vol. 70, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/55101.