Transition metal compound mediated reduction of alpha-amino acids to 1,2-amino alcohols with NaBH4 in water

Date

1999-01-01

Author

Demir, Ayhan Sıtkı
Akhmedov, IM
Sesenoglu, O

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A new efficient and cost-effective method for the preparation of 1,2-amino alcohols is described. The reactions of amino acids with NaBH4 in the presence of NiCl2 or MoO3 in water give 1,2-amino alcohols in high yield. When optically pure amino acids were used, optically pure 1,2-amino alcohols were obtained.

Subject Keywords

O-alkyl ethers, Sodıum-borohydrıde, Enantıoselectıve reductıon, Asymmetric-synthesis, Salt systems, Hydrogenation, Derivatives, Convenİent, Chloride, Ketones

URI

https://hdl.handle.net/11511/55226

Journal

TURKISH JOURNAL OF CHEMISTRY

Collections

Department of Chemistry, Article

Citation Formats

A. S. Demir, I. Akhmedov, and O. Sesenoglu, “Transition metal compound mediated reduction of alpha-amino acids to 1,2-amino alcohols with NaBH4 in water,” TURKISH JOURNAL OF CHEMISTRY, vol. 23, no. 2, pp. 123–126, 1999, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/55226.