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Transition metal compound mediated reduction of alpha-amino acids to 1,2-amino alcohols with NaBH4 in water

Demir, Ayhan Sıtkı
Akhmedov, IM
Sesenoglu, O
A new efficient and cost-effective method for the preparation of 1,2-amino alcohols is described. The reactions of amino acids with NaBH4 in the presence of NiCl2 or MoO3 in water give 1,2-amino alcohols in high yield. When optically pure amino acids were used, optically pure 1,2-amino alcohols were obtained.