Preparation of fluorescent IgG monoclonal antibody conjugated PHB coated magnetic nonoparticles for imaging and cancer therapy

Preparation of silica coated cobalt ferrite magnetic nanoparticles for the purification of histidine-tagged proteins Aygar, Gülfem; Volkan, Mürvet; Özkan, Necati; Department of Micro and Nanotechnology (2011) The magnetic separation approach has several advantages compared with conventional separation methods; it can be performed directly in crude samples containing suspended solid materials without pretreatment, and can easily isolate some biomolecules from aqueous systems in the presence of magnetic gradient fields. This thesis focused on the development of new class of magnetic separation material particularly useful for the separation of histidine-tagged proteins from the complex matrixes through the use of ...
Development of poly (I:C) modified doxorubicin loaded magnetic dendrimer nanoparticles for targeted combination therapy Khodadust, Rouhollah; Unsoy, Gozde; Gündüz, Ufuk (2014-10-01) The objective of this study was to develop and evaluate the anticancer activity and the safety of a combinational drug delivery system using polyamidoamine (PAMAM) dendrimer-coated iron oxide nanoparticles for doxorubicin and poly I:C delivery in vitro. Dendrimer-coated magnetic nanoparticles (DcMNPs) are suitable for drug delivery system as nanocarriers with their following properties, such as surface functional groups, symmetry perfection, internal cavities, nano-size and magnetization. These nanoparticle...
Synthesis of Doxorubicin loaded magnetic chitosan nanoparticles for pH responsive targeted drug delivery ÜNSOY, GÖZDE; Khodadust, Rouhollah; Yalcin, Serap; Mutlu, Pelin; Gündüz, Ufuk (2014-10-01) Targeted drug delivery is a promising alternative to overcome the limitations of classical chemotherapy. In an ideal targeted drug delivery system carrier nanoparticles would be directed to the tumor tissue and selectively release therapeutic molecules. As a novel approach, chitosan coated magnetic nanoparticles (CS MNPs) maintain a pH dependent drug delivery which provides targeting of drugs to the tumor site under a magnetic field. Among various materials, chitosan has a great importance as a pH sensitive...
Synthesis of poly (dl-lactic-co-glycolic acid) coated magnetic nanoparticles for anti-cancer drug delivery Tansık, Gülistan; Gündüz, Ufuk; Department of Biology (2012) One of the main problems of current cancer chemotherapy is the lack of selectivity of anti-cancer drugs to tumor cells which leads to systemic toxicity and adverse side effects. In order to overcome these limitations, researches on controlled drug delivery systems have gained much attention. Nanoscale based drug delivery systems provide tumor targeting. Among many types of nanocarriers, superparamagnetic nanoparticles with their biocompatible polymer coatings can be targeted to an intented site by an extern...
Preparation of silica coated cobalt ferrite magnetic nanoparticles for the purification of histidine-tagged proteins Aygar, Gulfem; Kaya, Murat; Özkan, Necati; Kocabıyık, Semra; Volkan, Mürvet (2015-12-01) Surface modified cobalt ferrite (CoFe2O4) nanoparticles containing Ni-NTA affinity group were synthesized and used for the separation of histidine tag proteins from the complex matrices through the use of imidazole side chains of histidine molecules. Firstly, CoFe2O4 nanoparticles with a narrow size distribution were prepared in an aqueous solution using the controlled co-precipitation method. In order to obtain small CoFe2O4 agglomerates, oleic acid and sodium chloride were used as dispersants. The CoFe2O4...

Citation Formats

S. Yalcin, G. Unsoy, N. T. Pourianazar, and U. Gündüz, “Preparation of fluorescent IgG monoclonal antibody conjugated PHB coated magnetic nonoparticles for imaging and cancer therapy,” 2014, vol. 281, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/55692.