Enantioselective synthesis of alpha-hydroxy ketones via benzaldehyde lyase-catalyzed C-C bond formation reaction

Date

2002-01-01

Author

Demir, Ayhan Sıtkı
Sesenoglu, O
Eren, E
Hosrik, B
Pohl, M
Janzen, E
Kolter, D
Feldmann, R
Dunkelmann, P
Muller, M

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(R)-Benzoins and (R) -2-hydroxypropiophenone derivatives are formed on a preparative scale by benzaldehyde lyase (BAL)-catalyzed C-C bond formation from aromatic aldehydes and acetaldehyde in aqueous buffer/DMSO solution with remarkable case in high chemical yield and high optical purity. The substrate range of this thiamin diphosphate-dependent enzyme was examined with respect to a broad applicability of this benzoin condensation-type reaction in stereoselective synthesis.

Subject Keywords

Organic Chemistry, General Chemistry, Catalysis

URI

https://hdl.handle.net/11511/56432

Journal

ADVANCED SYNTHESIS & CATALYSIS

DOI

https://doi.org/10.1002/1615-4169(200201)344:1<96::aid-adsc96>3.0.co;2-z

Collections

Department of Chemistry, Article

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Citation Formats

A. S. Demir et al., “Enantioselective synthesis of alpha-hydroxy ketones via benzaldehyde lyase-catalyzed C-C bond formation reaction,” ADVANCED SYNTHESIS & CATALYSIS, pp. 96–103, 2002, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/56432.