The efficacy of bioceramics for the closure of burr-holes in craniotomy: Case studies on 14 patients

Izci, Yusuf
Secer, Halil Ibrahim
Ilica, Ahmet Turan
Karacalioglu, Ozgur
Onguru, Onder
Timucin, Muharrem
Korkusuz, Feza
Purpose: Bioceramics are currently in use to cover bone defects in orthopedics and craniofacial surgery. But their compatibility and efficacy in cranium were not investigated in detail. The aims of this study were to produce, characterize, and assess the biocompatibility and osteointegration of Si-HA, Si-Sr-HA, HA-Wollastonite, and HA-Wollastonite-Frit bioceramics.


Preparation and characterization of chitosan-gelatin/hydroxyapatite scaffolds for hard tissue engineering approaches
Işıklı, Cansel; Hasırcı, Nesrin; Department of Biomedical Engineering (2010)
Hard tissue engineering holds the promise of restoring the function of failed hard tissues and involves growing specific cells on extracellular matrix (ECM) to develop „„tissue-like” structures or organoids. Chitosan is a linear amino polysaccharide that can provide a convenient physical and biological environment in tissue regeneration attempt. To improve chitosan‟s mechanical and biological properties, it was blended with another polymer gelatin. 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide (EDC) and N-...
Development of vascularized adipose tissue construct based on adipose tissue extracellular matrix and silk fibroin
Kayabölen, Alişan; Tezcaner, Ayşen; Zor, Fatih; Department of Biomedical Engineering (2015)
Adipose tissue engineering is a promising field for regeneration of soft tissue defects. However, vascularization is needed since cells in the middle layer of thick implants cannot reach to nutrient and oxygen by diffusion. Finding a biocompatible scaffold with good mechanical properties is another problem in this field. In this study, we aimed to develop a thick functional vascularized adipose tissue which supports cell viability and functionality with similar mechanical properties with the adipose tissue....
Development of microcarrier systems for bone tissue engineering
Aydoğdu, Hazal; Tezcaner, Ayşen; Baran, Erkan Türker; Department of Biomedical Engineering (2015)
Current strategies in bone tissue engineering have largely focused on development of carrier systems for repair and regeneration of bone tissue defects. The microcarrier systems offer an efficient method of delivery of cells with non-invasive injectable system. In this study, three-dimensional hydrogel microspheres were developed via water-in-oil emulsion method. In the first part of the thesis, porous pullulan (PULL) microspheres, with average size of 153±46 µm, were prepared and the surface of the microsp...
In Vivo Performance of Poly(epsilon-caprolactone) Constructs Loaded with Gentamicin Releasing Composite Microspheres for Use in Bone Regeneration
Sezer, Umran Aydemir; BİLLUR, DENİZ; HURİ, GAZİ; Huri, Pinar Yilgor; AKSOY, EDA AYŞE; Terzioglu, Hakan; Konukseven, Erhan İlhan; Hasırcı, Vasıf Nejat; Hasırcı, Nesrin (2014-10-01)
For materials used in the production of dental and orthopedic implants or scaffolds for bone tissue regeneration, the properties such as capacity to enhance cell attachment and proliferation, and antimicrobial activity to prevent biofilm formation are very important to improve the clinical utility of the material. In this study, poly(epsilon-caprolactone) (PCL) sponges with antimicrobial activity were prepared by incorporating gentamicin loaded beta-tricalcium phosphate (beta-TCP)-Gelatin microspheres, and ...
The role of multiple toll-like receptor signalling cascades on interactions between biomedical polymers and dendritic cells
Shokouhi, Behnaz; Coban, Cevayir; Hasırcı, Vasıf Nejat; Aydin, Erkin; Dhanasingh, Anandhan; Shi, Nian; Koyama, Shohei; Akira, Shizuo; Zenke, Martin; Sechi, Antonio S. (2010-08-01)
Biomaterials are used in several health-related applications ranging from tissue regeneration to antigen-delivery systems. Yet, biomaterials often cause inflammatory reactions suggesting that they profoundly alter the homeostasis of host immune cells such as dendritic cells (DCs). Thus, there is a major need to understand how biomaterials affect the function of these cells. In this study, we have analysed the influence of chemically and physically diverse biomaterials on DCs using several murine knockouts. ...
Citation Formats
Y. Izci et al., “The efficacy of bioceramics for the closure of burr-holes in craniotomy: Case studies on 14 patients,” JOURNAL OF APPLIED BIOMATERIALS & FUNCTIONAL MATERIALS, pp. 187–196, 2013, Accessed: 00, 2020. [Online]. Available: