The efficacy of bioceramics for the closure of burr-holes in craniotomy: Case studies on 14 patients

Izci, Yusuf
Secer, Halil Ibrahim
Ilica, Ahmet Turan
Karacalioglu, Ozgur
Onguru, Onder
Timucin, Muharrem
Korkusuz, Feza
Purpose: Bioceramics are currently in use to cover bone defects in orthopedics and craniofacial surgery. But their compatibility and efficacy in cranium were not investigated in detail. The aims of this study were to produce, characterize, and assess the biocompatibility and osteointegration of Si-HA, Si-Sr-HA, HA-Wollastonite, and HA-Wollastonite-Frit bioceramics.


Improvement of bioactivity with dual bioceramic incorporation to nanofibrous PCL scaffolds
Altunordu, Gercem; Tezcaner, Ayşen; Evis, Zafer; Keskin, Dilek (2023-03-01)
Bone tissue injuries, diseases or related clinical interventions require bone tissue engineering (BTE) approaches for regeneration of large bone defects, especially for compromised situations. Most BTE applications in literature focused on composites of polymers with a single type of bioceramic. However, native bone matrix has various inorganic components. Accordingly, this study aimed to investigate the use of dual bioceramics in BTE scaffolds prepared by wet-electrospinning of Poly-caprolactone (PCL) and ...
Development of manganese-doped hydroxyapatite incorporated PCL electrospun 3D scaffolds coated with gelatin for bone tissue engineering
Samiei, Alaleh; Keskin, Dilek; Evis, Zafer; Department of Biomedical Engineering (2023-1-27)
Combination of polymers and bioceramics has increased their importance in bone tissue engineering (BTE) to treat various defects. Within this frame, in this thesis, it is aimed to develop a 3D gelatin-coated PCL scaffold combined with Mn-doped hydroxyapatite (HA) in order to investigate the effect of the doping element, i.e., the manganese (Mn) ion, on the structural and biological properties of the composite scaffold. Pure and Mn-doped HAs were synthesized using microwave irradiation, and the samples were ...
Preparation and characterization of chitosan-gelatin/hydroxyapatite scaffolds for hard tissue engineering approaches
Işıklı, Cansel; Hasırcı, Nesrin; Department of Biomedical Engineering (2010)
Hard tissue engineering holds the promise of restoring the function of failed hard tissues and involves growing specific cells on extracellular matrix (ECM) to develop „„tissue-like” structures or organoids. Chitosan is a linear amino polysaccharide that can provide a convenient physical and biological environment in tissue regeneration attempt. To improve chitosan‟s mechanical and biological properties, it was blended with another polymer gelatin. 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide (EDC) and N-...
Development of microcarrier systems for bone tissue engineering
Aydoğdu, Hazal; Tezcaner, Ayşen; Baran, Erkan Türker; Department of Biomedical Engineering (2015)
Current strategies in bone tissue engineering have largely focused on development of carrier systems for repair and regeneration of bone tissue defects. The microcarrier systems offer an efficient method of delivery of cells with non-invasive injectable system. In this study, three-dimensional hydrogel microspheres were developed via water-in-oil emulsion method. In the first part of the thesis, porous pullulan (PULL) microspheres, with average size of 153±46 µm, were prepared and the surface of the microsp...
In Vivo Performance of Poly(epsilon-caprolactone) Constructs Loaded with Gentamicin Releasing Composite Microspheres for Use in Bone Regeneration
Sezer, Umran Aydemir; BİLLUR, DENİZ; HURİ, GAZİ; Huri, Pinar Yilgor; AKSOY, EDA AYŞE; Terzioglu, Hakan; Konukseven, Erhan İlhan; Hasırcı, Vasıf Nejat; Hasırcı, Nesrin (2014-10-01)
For materials used in the production of dental and orthopedic implants or scaffolds for bone tissue regeneration, the properties such as capacity to enhance cell attachment and proliferation, and antimicrobial activity to prevent biofilm formation are very important to improve the clinical utility of the material. In this study, poly(epsilon-caprolactone) (PCL) sponges with antimicrobial activity were prepared by incorporating gentamicin loaded beta-tricalcium phosphate (beta-TCP)-Gelatin microspheres, and ...
Citation Formats
Y. Izci et al., “The efficacy of bioceramics for the closure of burr-holes in craniotomy: Case studies on 14 patients,” JOURNAL OF APPLIED BIOMATERIALS & FUNCTIONAL MATERIALS, pp. 187–196, 2013, Accessed: 00, 2020. [Online]. Available: