Transcriptional Swithes For Ere-Driven Genes

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2012-12-31

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Muyan, Mesut

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Estrogen hormones, particularly 17β-estradiol (E2), play critical roles in the initiation and development of breast cancer. E2 effects are mediated by estrogen receptors (ERs) acting as transcription factors. The current approaches for breast cancer treatment involve agents to reduce/ablate the circulating E2 and to alter/prevent ER function. However, the absence/loss of ER expression, perturbations of E2 and/or ER environments together with circumvention of E2/ER mediated events by aberrant growth factor signaling render such approaches ineffective, necessitating the development of new modalities to combat the disease. The interaction of ER with specific DNA sequences, estrogen responsive elements (EREs), of responsive gene is a required route to induce cellular responses. Therefore, targeted regulation of ERE-driven genes with controllable artificial transcriptional factors could provide a means for the development of an additional/alternative approach for breast cancer treatment. Our aim is to establish a transcriptional on-off switch for the temporal regulation of estrogen responsive genes by specifically targeting EREs.

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https://hdl.handle.net/11511/61871

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Department of Biology, Project and Design

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Citation Formats

M. Muyan, “Transcriptional Swithes For Ere-Driven Genes,” 2012. Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/61871.