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Liver cancer cells are sensitive to Lanatoside C induced cell death independent of their PTEN status
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Date
2016-01-15
Author
Durmaz, Irem
Guven, Ebru Bilget
Erşahin, Tülin
ÖZTÜRK, MEHMET
Calis, Ihsan
Atalay, Rengül
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Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
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Background: Hepatocellular carcinoma is the second deadliest cancer with limited treatment options. Loss of PTEN causes the P13K/Akt pathway to be hyperactive which contributes to cell survival and resistance to therapeutics in various cancers, including the liver cancer. Hence molecules targeting this pathway present good therapeutic strategies for liver cancer.
Subject Keywords
Complementary and alternative medicine
,
Molecular Medicine
,
Pharmacology
,
Drug Discovery
,
Pharmaceutical Science
URI
https://hdl.handle.net/11511/63014
Journal
PHYTOMEDICINE
DOI
https://doi.org/10.1016/j.phymed.2015.11.012
Collections
Graduate School of Informatics, Article