Clinical significance of cerebroplacental ratio

Download

index.pdf

Date

2018-12-01

Author

Kalafat, Erkan
Khalil, Asma

Metadata

Show full item record

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Item Usage Stats

58
views

0
downloads

Purpose of review Two-thirds of the pregnancies complicated by stillbirth demonstrate growth restriction. Identification of the foetus at risk of growth restriction is essential to reduce the risk of stillbirth. The aim of this review is to critically appraise the current evidence regarding clinical utility of cerebroplacental ratio (CPR) in antenatal surveillance. Recent findings The CPR has emerged as an assessment tool for foetuses at increased risk of growth disorders. CPR is a better predictor of adverse events compared with middle-cerebral artery or umbilical artery Doppler alone. The predictive value of CPR for adverse perinatal outcomes is better for suspected small-for-gestational age foetuses compared with appropriate-for-gestational age (AGA) foetuses. CPR could be useful for the risk stratification of small-for-gestational age foetuses to determine the timing of delivery and also to calculate the risk of intrapartum compromise or prolonged admission to the neonatal care unit. Although there are many proposed cut-offs for an abnormal CPR value, evidence is currently lacking to suggest the use of one cut-off over another. CPR appears to be associated with increased risk of intrapartum foetal compromise, abnormal growth velocity, and lower birthweight in AGA foetuses as well. Moreover, birthweight differences are better explained with CPR compared to other factors such as ethnicity. However, the role of CPR in predicting adverse perinatal outcomes such as acidosis or low Apgar scores in AGA foetuses is yet to be determined. CPR appears to be a useful surrogate of suboptimal foetal growth and intrauterine hypoxia and it is associated with a variety of perinatal adverse events.

Subject Keywords

Obstetrics and Gynaecology

URI

https://hdl.handle.net/11511/65640

Journal

CURRENT OPINION IN OBSTETRICS & GYNECOLOGY

DOI

https://doi.org/10.1097/gco.0000000000000490

Collections

Department of Statistics, Article

Suggestions

OpenMETU
Core

The role of aspirin in prevention of preeclampsia in twin pregnancies: does the dose matter? Kalafat, Erkan; Shirazi, Amani; Thilaganathan, Basky; Khalil, Asma (Elsevier BV, 2020-09-01) Objective The use of aspirin in twin pregnancies for the prevention of preeclampsia is a controversial topic, and evidence on the required dose of aspirin is scarce. We aimed to assess the efficacy of 75 mg/day vs 150 mg/day aspirin for the prevention of preeclampsia in twin pregnancies. Study Design This is a retrospective cohort study of twin pregnancies managed at St George’s University Hospital between 2012 and 2019. The National Institute for Health and Care Excellence guideline published in 2010 has...
Is umbilicocerebral ratio better than cerebroplacental ratio for predicting adverse pregnancy and neonatal outcomes? Kalafat, Erkan; Kalaylioglu, Zeynep; Thilaganathan, Basky; Khalil, Asma (Elsevier BV, 2020-09-01) Objective A secondary analysis of the trial of randomized umbilical and fetal flow in Europe suggested that the umbilicocerebral ratio (UCR) provides better differentiation of neurodevelopmental outcome in the abnormal range compared with that of the cerebroplacental ratio (CPR).1 However, the reported superiority of UCR is controversial.2 This study aimed to compare the CPR and the UCR for predicting operative delivery for presumed fetal compromise and prolonged neonatal unit (NNU) admission in term fetus...
Risk of operative delivery for intrapartum fetal compromise in small-for-gestational-age fetuses at term: an internally validated prediction model Kalafat, Erkan; Morales-Rosello, Jose; Thilaganathan, Basky; Tahera, Fathema; Khalil, Asma (Elsevier BV, 2018-01-01) BACKGROUND: Small-for-gestational-age fetuses are at an increased risk of intrapartum fetal compromise requiring operative delivery. Factors associated with the risk of intrapartum fetal compromise are yet to be established, and a comprehensive model accounting for both the antenatal and intrapartum variables is lacking.
The outcome of the multifetal pregnancy reduction procedures in a single centre: A report of 202 completed cases Yilanhoglu, Necip Cihangir; Semiz, Altug; Arisoy, Resul; Kahraman, Semra; Gurkan, Ali Arslan (Elsevier BV, 2018-11-01) Objective: To review the results of fetal reduction procedures in our institution, evaluate its effects on the pregnancy outcome in terms of miscarriage, preterm delivery, taking home healthy babies and discuss the factors that may have contributed to the outcome.
Genetic aspects of human male infertility: the frequency of chromosomal abnormalities and Y chromosome microdeletions in severe male factor infertility Vicdan, A; Vicdan, K; Gunalp, S; Kence, Aykut; Akarsu, C; Isik, AZ; Sozen, E (Elsevier BV, 2004-11-10) Objective: The main purpose of this, study is to detect the frequency and type of both chromosomal abnormalities and Y chromosome microdeletions in patients with severe male factor infertility and fertile control subjects. The association between the genetic abnormality and clinical parameters was also evaluated. Methods: This study was carried out in 208 infertile and 20 fertile men. Results of 208 patients, 1 19 had non-obstructive azoospermia and 89 had severe oligoasthenoteratozoospermia (OAT). Seventee...

Citation Formats

E. Kalafat and A. Khalil, “Clinical significance of cerebroplacental ratio,” CURRENT OPINION IN OBSTETRICS & GYNECOLOGY, pp. 344–354, 2018, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/65640.