A novel photosensitizer based on a ruthenium(ii) phenanthroline bis(perylenediimide) dyad: synthesis, generation of singlet oxygen and in vitro photodynamic therapy

Date

2018-11-07

Author

Aksakal, Nuray Esra
Kazan, Hasan Huseyin
Ecik, Esra Tanriverdi
YÜKSEL, FATMA

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In this study, a novel photosensitizer having two perylenediimide units and a phenanthroline ruthenium(ii) coordination moiety (Ru-BP) has been developed for photodynamic therapy (PDT) of cancer cells. This new compound was prepared via reactions of two newly designed molecules, namely, 5,6,12,13-tetrakis(4-(tert-butyl)phenoxy)-2-(2,6-diisopropylphenyl)-9-(4-hydroxyphenyl)anthra[2,1,9-def:6,5,10-def]diisoquinoline-1,3,8,10(2H,9H)-tetraone (P6) and a bis(2,2-bipyridyl)-(4,7-dichlorophenanthroline)ruthenium(ii) complex (7). The singlet oxygen production of P6 and Ru-BP was investigated by a chemical method using 1,3-diphenylisobenzofurane as a trap molecule. Additionally, photodynamic therapy efficacy of the novel Ru-BP complex and P6 was evaluated in vitro. Ru-BP significantly decreased the viability of human chronic myeloid leukemia cells under red light but not in the dark, pointing out that the complex, itself, was not cytotoxic and singlet oxygen formation was required for the initiation of cell death mechanisms. Thus, Ru-BP can be effectively used as a photosensitizer in photodynamic therapy, which makes the novel Ru-BP a promising singlet oxygen generator for further biological applications.

Subject Keywords

Materials Chemistry, General Chemistry, Catalysis

URI

https://hdl.handle.net/11511/67358

Journal

NEW JOURNAL OF CHEMISTRY

DOI

https://doi.org/10.1039/c8nj02944j

Collections

Department of Biology, Article

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Citation Formats

N. E. Aksakal, H. H. Kazan, E. T. Ecik, and F. YÜKSEL, “A novel photosensitizer based on a ruthenium(ii) phenanthroline bis(perylenediimide) dyad: synthesis, generation of singlet oxygen and in vitro photodynamic therapy,” NEW JOURNAL OF CHEMISTRY, pp. 17538–17545, 2018, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/67358.