AMINOCYCLANOLS .2. STEREOCHEMICAL STUDIES ON A NEW CIRAMADOL ANALOG BY NMR-SPECTROSCOPY

1994-12-01
BURGEMEISTER, T
OZARSLAN, O
ERTAN, M
AKGUN, H
WIEGREBE, W
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The absol. configuration of a Ciramadol analogue obtained from (-)-menthone is established by H-1-NMR-, simulated NMR-, COSY-90-, and NOE-measurements. The final compound 2-(alpha-1-pyrrolidino)benzyl-4-isopropyl-1-methyl-cyclohexan-3-one (4b), e.g., has 1R,2S,4S,11S-configuration due to stereoselective Michael-type addition of pyrrolidine to the pertinent benzylidene intermediate 3.
Drug Discovery, Pharmaceutical Science
https://hdl.handle.net/11511/67898
ARCHIV DER PHARMAZIE
Department of Chemistry, Article

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Citation Formats
T. BURGEMEISTER, O. OZARSLAN, M. ERTAN, H. AKGUN, and W. WIEGREBE, “AMINOCYCLANOLS .2. STEREOCHEMICAL STUDIES ON A NEW CIRAMADOL ANALOG BY NMR-SPECTROSCOPY,” ARCHIV DER PHARMAZIE, pp. 785–787, 1994, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/67898.
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