Poly(D,L-lactide/epsilon-caprolactone)/hydroxyapatite composites as bone filler: An in vivo study in rats

Date

2002-12-01

Author

Senkoylu, A
Ural, E
Kesenci, K
Simsek, A
Ruacan, S
Fambri, L
Migliaresi, C
Piskin, E

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In this study, a novel composite bone substitute was implanted in animal models (rats) and their in vivo characteristics were examined. A D,L-lactide and epsilon-caprolactone copolymer (M(W): 80,000; M(n):40,000, and PI:2.00) was synthesized by ring-opening polymerization of the respective dimers using stannous octoate as the catalyst. The final ratio of D,L-lactide to epsilon-caprolactone obtained by (1)NMR was 60/40. Hydroxyapatite (HA) powder was loaded in the copolymer. The HA/copolymer ratio was 60/40 (w/w). These composites were easily shaped by hand. Animal tests were performed on mature wistar rats (n=30). Defects were created on the proximal, the thickest part of the femur. The bone defects of the first group were filled with polymer/HA composite, the second group filled with only HA and the third group was left empty. Histologic examination of bone tissues showed new bone formation around the yellow-green polymer/HA composite material in the first group of animals whereas no evidence of new bone growth was observed in other groups.

Subject Keywords

Bone filler composite, Poly(D,L-lactide/epsilon-caprolactone) copolymers, Hydroxyapatite, Animal tests

URI

https://hdl.handle.net/11511/68479

Journal

INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS

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Citation Formats

A. Senkoylu et al., “Poly(D,L-lactide/epsilon-caprolactone)/hydroxyapatite composites as bone filler: An in vivo study in rats,” INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS, pp. 1174–1179, 2002, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/68479.