Arid4b is critical for mouse embryonic stem cell differentiation towards mesoderm and endoderm, linking epigenetics to pluripotency exit.

Date

2020-10-15

Author

Terzi Çizmecioğlu, Nihal
Keskin, Ezgi G
Wang, Xiaofeng
Esen, Idil
Chen, Fei
Orkin, Stuart H

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

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URI

https://hdl.handle.net/11511/69513

Journal

The Journal of biological chemistry

DOI

https://doi.org/10.1074/jbc.ra120.015534

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Department of Biology, Article

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Arid4b alters cell cycle and cell death dynamics during mouse embryonic stem cell differentiation. Güven, Gözde; Terzi Çizmecioğlu, Nihal (2021-02-09) Cell division and death play an important role in embryonic development. Cell specialization is accompanied with slow proliferation and quiescence. Cell death is important for morphogenesis. Gene expression changes during differentiation is coordinated by lineage-specific transcription factors and chromatin factors. It is not yet fully understood how alterations in gene expression and cell cycle/death mechanisms are connected. We previously identified a chromatin protein Arid4b as a critical factor for meso...
ARID3B expression in primary breast cancers and breast cancer-derived cell lines ERDOGAN, Ayse Selcen Oguz; OZDEMIRLER, Nihan; ÖYKEN, MERVE; ALPER, Murat; Erson Bensan, Ayşe Elif (2014-08-01) ARID3B (AT-rich interaction domain 3) is a member of the family of ARID proteins, which constitutes evolutionarily conserved transcription factors implicated in normal development, differentiation, cell cycle regulation and chromatin remodeling. In addition, ARID3B has been linked to cellular immortalization, epithelial-mesenchymal transition (EMT) and tumorigenesis. Given the emerging role of ARID3B in tumor development, we examined its expression in primary patient-derived breast cancer samples and breast...
Arid4b physically interacts with Tfap2c in mouse embryonic stem cells Keskin, Ezgi Gul; Huang, Jialiang; Terzi Çizmecioğlu, Nihal (2021-01-01) Precise regulation of gene expression is required for embryonic stem cell (ESC) differentiation. Transcription factor (TF) networks coordinate the balance of pluripotency and differentiation in response to extracellular and intracellular signals. Chromatin factors work alongside TFs to achieve timely regulation of gene expression for differentiation process. Our previous studies showed that a member of the Sin3a corepressor complex, Arid4b, is critical for proper mouse ESC differentiation into mesoderm and ...
ARID3B expression in primary breast cancer samples Oğuz Erdoğan, Ayşe Selcen; Erson Bensan, Ayşe Elif; Department of Biology (2014) ARID3B (AT-rich interaction domain 3) is a member of the family of ARID proteins, which constitutes evolutionarily conserved transcription factors implicated in normal development, differentiation, cell cycle regulation and chromatin remodeling. In addition, ARID3B has been linked to cellular immortalization, epithelial-mesenchymal transition (EMT) and tumorigenesis. Given the emerging roles of ARID3B in tumor development, we examined its expression in primary patient-derived breast cancer samples to furthe...
RanBPM (RanBP9) regulates mouse c-Kit receptor level and is essential for normal development of bone marrow progenitor cells. Puverel, S; Kiriş, Erkan; Singh, S; Klarmann, KD; Coppola, V; Keller, JR; Tessarollo, L (Impact Journals, LLC, 2016-12-20) c-Kit is a tyrosine kinase receptor important for gametogenesis, hematopoiesis, melanogenesis and mast cell biology. Dysregulation of c-Kit function is oncogenic and its expression in the stem cell niche of a number of tissues has underlined its relevance for regenerative medicine and hematopoietic stem cell biology. Yet, very little is known about the mechanisms that control c-Kit protein levels. Here we show that the RanBPM/RanBP9 scaffold protein binds to c-Kit and is necessary for normal c-Kit protein e...

Citation Formats

N. Terzi Çizmecioğlu, E. G. Keskin, X. Wang, I. Esen, F. Chen, and S. H. Orkin, “Arid4b is critical for mouse embryonic stem cell differentiation towards mesoderm and endoderm, linking epigenetics to pluripotency exit.,” The Journal of biological chemistry, 2020, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/69513.