Synthesis, Cytotoxicity and Structure-Activity Relationships of Novel Isoxazole. Derivatives as Anticancer Agents

İbiş, Kübra
Çalışkan, Burcu
Akhan Güzelcan, Ece
Sinoplu, Esra
Atalay, Rengül
Banoğlu, Erden


Synthesis, Characterization and Evaluation of Cytotoxic Activities of Novel Aziridinyl Phosphonic Acid Derivatives
Khan, Rehan; Ulusan, Sinem; Banerjee, Sreeparna; Doğan, Özdemir (Wiley, 2019-11-01)
New aziridine 2-phosphonic acids were prepared by monohydrolysis of the aziridine 2-phosphonates that were obtained by the modified Gabriel-Cromwell reaction of vinyl phosphonate or alpha-tosylvinyl phosphonate with a primary amine or a chiral amine. The cellular cytotoxicity of these compounds was tested against the HCT-116 colorectal cancer cell lines and the CCD-18Co normal colon fibroblast lines using the MTT assay. Three of the synthesized phosphonic acid derivatives 2e (ethyl hydrogen {(2S)-1-[(1S)-1-...
Synthesis and cellular bioactivities of novel isoxazole derivatives incorporating an arylpiperazine moiety as anticancer agents.
ÇALIŞKAN, BURCU; Nalbat, Esra; Ibis, Kubra; Guzelcan, Ece Akhan; Atalay, Rengül; BANOĞLU, ERDEN (2018-12-01)
In our endeavour towards the development of effective anticancer therapeutics, a novel series of isoxazole-piperazine hybrids were synthesized and evaluated for their cytotoxic activities against human liver (Huh7 and Mahlavu) and breast (MCF-7) cancer cell lines. Within series, compounds 51-o showed the most potent cytotoxicity on all cell lines with IC50 values in the range of 0.3-3.7 mu M. To explore the mechanistic aspects fundamental to the observed activity, further biological studies with 5m and 5o i...
Synthesis, crosslinking and characterization of glycidyl azide like polymers.
Polat, Kinyas; Alyürük, Kemal; Department of Polymer Science and Technology (2002)
Synthesis and characterization of copolymers of ethyleneterephthalate oligomers and p-acetoxybenzoic acid.
Ateş, Cengiz; Bayramlı, Erdal; Department of Polymer Science and Technology (2002)
Synthesis, Anticancer Activity and Docking Studies of New Phenylaminopyrimidine Derivatives
Demirci, Aslı; Durmaz, İrem; Atalay, Rengül; Küçükgüzel, İlkay (null; 2017-06-25)
Citation Formats
K. İbiş, B. Çalışkan, E. Akhan Güzelcan, E. Sinoplu, R. Atalay, and E. Banoğlu, “Synthesis, Cytotoxicity and Structure-Activity Relationships of Novel Isoxazole. Derivatives as Anticancer Agents,” presented at the RICT, (2018), 2018, Accessed: 00, 2021. [Online]. Available: