Synthesis, Cytotoxicity and Structure-Activity Relationships of Novel Isoxazole. Derivatives as Anticancer Agents

Date

2018-07-04

Author

İbiş, Kübra
Çalışkan, Burcu
Akhan Güzelcan, Ece
Sinoplu, Esra
Atalay, Rengül
Banoğlu, Erden

Metadata

Show full item record

Item Usage Stats

93
views

0
downloads

URI

https://hdl.handle.net/11511/72502

Conference Name

RICT, (2018)

Collections

Graduate School of Informatics, Conference / Seminar

Suggestions

OpenMETU
Core

Synthesis, Characterization and Evaluation of Cytotoxic Activities of Novel Aziridinyl Phosphonic Acid Derivatives Khan, Rehan; Ulusan, Sinem; Banerjee, Sreeparna; Doğan, Özdemir (Wiley, 2019-11-01) New aziridine 2-phosphonic acids were prepared by monohydrolysis of the aziridine 2-phosphonates that were obtained by the modified Gabriel-Cromwell reaction of vinyl phosphonate or alpha-tosylvinyl phosphonate with a primary amine or a chiral amine. The cellular cytotoxicity of these compounds was tested against the HCT-116 colorectal cancer cell lines and the CCD-18Co normal colon fibroblast lines using the MTT assay. Three of the synthesized phosphonic acid derivatives 2e (ethyl hydrogen {(2S)-1-[(1S)-1-...
Synthesis and cellular bioactivities of novel isoxazole derivatives incorporating an arylpiperazine moiety as anticancer agents. ÇALIŞKAN, BURCU; Nalbat, Esra; Ibis, Kubra; Guzelcan, Ece Akhan; Atalay, Rengül; BANOĞLU, ERDEN (2018-12-01) In our endeavour towards the development of effective anticancer therapeutics, a novel series of isoxazole-piperazine hybrids were synthesized and evaluated for their cytotoxic activities against human liver (Huh7 and Mahlavu) and breast (MCF-7) cancer cell lines. Within series, compounds 51-o showed the most potent cytotoxicity on all cell lines with IC50 values in the range of 0.3-3.7 mu M. To explore the mechanistic aspects fundamental to the observed activity, further biological studies with 5m and 5o i...
Synthesis, crosslinking and characterization of glycidyl azide like polymers. Polat, Kinyas; Alyürük, Kemal; Department of Polymer Science and Technology (2002)
Synthesis and characterization of copolymers of ethyleneterephthalate oligomers and p-acetoxybenzoic acid. Ateş, Cengiz; Bayramlı, Erdal; Department of Polymer Science and Technology (2002)
Synthesis, Anticancer Activity and Docking Studies of New Phenylaminopyrimidine Derivatives Demirci, Aslı; Durmaz, İrem; Atalay, Rengül; Küçükgüzel, İlkay (null; 2017-06-25)

Citation Formats

K. İbiş, B. Çalışkan, E. Akhan Güzelcan, E. Sinoplu, R. Atalay, and E. Banoğlu, “Synthesis, Cytotoxicity and Structure-Activity Relationships of Novel Isoxazole. Derivatives as Anticancer Agents,” presented at the RICT, (2018), 2018, Accessed: 00, 2021. [Online]. Available: https://hdl.handle.net/11511/72502.