Influence of Micropatterns on Human Mesenchymal Stem Cell Fate

Date

2015-10-22

Author

Hastürk, Onur
Hasırcı, Nesrin
Hasırcı, Vasıf Nejat

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https://hdl.handle.net/11511/72751

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Influence of Micropatterns on Human Mesencyhmal Stem Cell Fate Hastürk, Onur; Hasırcı, Nesrin; Hasırcı, Vasıf Nejat (2015-10-21)
Influence of STRO-1 selection on osteogenic potential of human tooth germ derived mesenchymal stem cells Ercal, Pinar; Pekozer, Gorke G.; Gumru, Osman Z.; KÖSE, GAMZE; Ramazanoglu, Mustafa (Elsevier BV, 2017-10-01) Mesenchymal stem cells derived from the human tooth germ (hTGSCs) are a heterogeneous cell population that can differentiate into osteogenic, neurogenic, and adipogenic lineages. The aim of this study was to compare the osteogenic differentiation capacity of STRO-1 positive (STRO-1 +) hTGSCs and unsorted heterogeneous hTGSCs and to establish if STRO-1 + cells are more committed to osteogenic differentiation. HTGSCs were isolated from impacted third molar tooth germ tissues of adolescents, and a subpopulatio...
Influence of the mesenchymal cell source on oral epithelial development Kinikoglu, Beste; Rovere, Marie Rose; Haftek, Marek; Hasırcı, Vasıf Nejat; Damour, Odile (2012-03-01) The extent of the influence of mesenchymal tissue on epithelial development is still debated, and elucidation of epithelialmesenchymal interactions should be of relevance for controlling normal as well as pathological growth and development. The aim of the present study was to elucidate the influence of the mesenchymal cell type on oral mucosa epithelial development in vitro, using tissue-engineering principles, by including three different sources for mesenchymal cell type, viz. oral mucosa, skin and corne...
Influence of micropatterns on human mesenchymal stem cell fate / Hastürk, Onur; Hasırcı, Vasıf Nejat; Hasırcı, Nesrin; Department of Biotechnology (2016) Mesenchymal stem cells (MSCs) are promising cell sources for tissue engineering applications as they can differentiate into a variety of adult cells types including osteoblasts. In vivo microenvironment of stem cells is known to provide both biochemical signals and micro- and nanoscale physical cues that influence the behavior and fate of stem cells. The use of soluble chemical factors is the most common strategy to guide the commitment of MSCs to specific lineages, but it is a cause of concern such as unsa...
Influence of stimulatory and suppressive DNA motifs on host susceptibility to inflammatory arthritis. Zeuner, RA; Verthelyi, D; Gürsel, Mayda; Ishii, KJ; Klinman, DM (Wiley, 2003-06-01) Objective. To examine whether systemic administration of immunostimulatory and immunosuppressive oligodeoxynucleotides (ODNs) alter host susceptibility to inflammatory arthritis. Methods. Normal BALB/c mice were treated systemically with CpG ODNs or suppressive ODNs, and then challenged intraarticularly with CpG DNA. The onset and magnitude of the resulting inflammatory response was monitored. Results. Systemic delivery of CpG ODNs significantly increased susceptibility to local inflammation, whereas syst...

Citation Formats

O. Hastürk, N. Hasırcı, and V. N. Hasırcı, “Influence of Micropatterns on Human Mesenchymal Stem Cell Fate,” 2015, Accessed: 00, 2021. [Online]. Available: https://hdl.handle.net/11511/72751.