New Steroidal 4-aminoquinolines Antagonize BoNT/A in mES-MNs in Post-intoxication Model

Date

2016-09-01

Author

Konstantinovic, Jelena M
Kiriş, Erkan
Zlatovic, M V
Bavari, Sina
Solaja, Bogdan

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https://hdl.handle.net/11511/74208

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New Steroidal 4-Aminoquinolines Antagonize Botulinum Neurotoxin Serotype A in Mouse Embryonic Stem Cell Derived Motor Neurons in Postintoxication Model. Konstantinović, J; Kiriş, Erkan; Kota, KP; Kugelman-Tonos, J; Videnović, M; Cazares, LH; Terzić, Jovanović; Verbić, TŽ; Andjelković, B; Duplantier, AJ; Bavari, S; Šolaja, BA (American Chemical Society (ACS), 2018-02-22) The synthesis and inhibitory potencies against botulinum neurotoxin serotype A light chain (BoNT/A LC) using in vitro HPLC based enzymatic assay for various steroidal, benzothiophene, thiophene, and adamantane 4-aminoquinoline derivatives are described. In addition, the compounds were evaluated for the activity against BoNT/A holotoxin in mouse embryonic stem cell derived motor neurons. Steroidal derivative 16 showed remarkable protection (up to 89% of uncleaved SNAP-25) even when administered 30 min postin...
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New hidden beauty molecules predicted by the local hidden gauge approach and heavy quark spin symmetry Xiao, C. W.; Özpineci, Altuğ; Oset, E. (2010-06-24) Using a coupled channel unitary approach, combining the heavy quark spin symmetry and the dynamics of the local hidden gauge, we investigate the meson-meson interaction with hidden beauty. We obtain several new states of isospin I = 0: six bound states, and weakly bound six more possible states which depend on the influence of the coupled channel effects.
New chiral synthons from the PLE catalyzed enantiomeric separation of 6-acetoxycyclohex-2-en-1-one derivatives. Tanyeli, Cihangir; Dikici, E (1997-09-07)

Citation Formats

J. M. Konstantinovic, E. Kiriş, M. V. Zlatovic, S. Bavari, and B. Solaja, “New Steroidal 4-aminoquinolines Antagonize BoNT/A in mES-MNs in Post-intoxication Model,” 2016, Accessed: 00, 2021. [Online]. Available: https://hdl.handle.net/11511/74208.