Alternative polyadenylation and its impact on cellular processes.

Date

2014-01-01

Author

Akman, Hb
Erson Bensan, Ayşe Elif

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URI

https://hdl.handle.net/11511/75774

Journal

MicroRNA (Shariqah, United Arab Emirates)

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Alternative polyadenylation and its impact on cellular processes Akman Tuncer, Hesna Begüm; Erson Bensan, Ayşe Elif (Bentham Science , 2014-01-01) Impact of mRNA processing and/or modifications has long been associated with gene expression regulation. Accumulating evidence shows alternative polyadenylation (APA), as an mRNA related process, to emerge as a widespread mechanism in gene expression regulation. Through selecting alternate (proximal or distal) polyadenylation signals on the 3'-UTR of pre-mRNAs, APA generates multiple transcript isoforms which may even create proteomic diversity. Depending on the use of proximal or distal polyadenylation sit...
Alternative Polyadenylation: Another Foe in Cancer Erson Bensan, Ayşe Elif; Can, Tolga (2016-06-01) Advancements in sequencing and transcriptome analysis methods have led to seminal discoveries that have begun to unravel the complexity of cancer. These studies are paving the way toward the development of improved diagnostics, prognostic predictions, and targeted treatment options. However, it is clear that pieces of the cancer puzzle are still missing. In an effort to have a more comprehensive understanding of the development and progression of cancer, we have come to appreciate the value of the noncoding...
Alternative polyadenylation and RNA-binding proteins Erson Bensan, Ayşe Elif (Bioscientifica, 2016-08-01) Our understanding of the extent of microRNA-based gene regulation has expanded in an impressive pace over the past decade. Now, we are beginning to better appreciate the role of 3'-UTR (untranslated region) cis-elements which harbor not only microRNA but also RNA-binding protein (RBP) binding sites that have significant effect on the stability and translational rate of mRNAs. To add further complexity, alternative polyadenylation (APA) emerges as a widespread mechanism to regulate gene expression by produci...
Alternative prototyping of large sized plastic parts by using CNC milling machines - a comparative study. Aytaç, Mete; Gökler, Mustafa İlhan; Department of Mechanical Engineering (2001)
Alternative polyadenylation analysis in myelodysplastic syndromes, glioblastoma and gastric cancer Çınkıllı, Tuna; Erson Bensan, Ayşe Elif; Department of Biology (2014) Alternative polyadenylation (APA) is the process by which different length transcript isoforms are generated. Upon the changes in poly(A) tail positioning, especially in the 3' untranslated regions (UTRs), resulting mRNA isoforms may be regulated differently by negative or positive regulatory elements. Under normal circumstances, differential APA patterns have been observed during development or proliferation events. Therefore, such differential preferences of polyadenylation sites may be important in proli...

Citation Formats

H. Akman and A. E. Erson Bensan, “Alternative polyadenylation and its impact on cellular processes.,” MicroRNA (Shariqah, United Arab Emirates), pp. 2–9, 2014, Accessed: 00, 2021. [Online]. Available: https://hdl.handle.net/11511/75774.