Allosuppressor Genes and the Control of Translation Fidelity in Yeast

İzgü, Kadri Fatih
Mf, Tuite
Cm, Grant


Allelic variation of the HLA-DQA1 and -DQB1 genes in Turkish population
Kantaroğlu, Nalan; Kence, Meral; Department of Biology (1999)
Allosteric changes in the centromere-specific nucleosome in response to physical factors
Önder, Onur; Boopathi, Ramachandran; Angelov, Dimitar; Dimitrov, Stefan; Kale, Seyit (Orta Doğu Teknik Üniversitesi Enformatik Enstitüsü; 2022-10)
Faithful segregation of sister chromatids is critical for the transfer of genetic inheritance during cell division. This is accomplished through the physical separation of these chromatids to the opposite cell poles via the spindle apparatus. Microtubular filaments of this apparatus attach to chromatin via kinetochores which assemble via direct recognition of the epigenetic factor CENP-A, known as a centromere-specific variant of histone H3. Histones are core protein components of nucleosomes which is a dis...
Endogenous signal peptides in recombinant protein production by Pichia pastoris: From in-silico analysis to fermentation
Massahi, Aslan; Çalık, Pınar (2016-11-07)
For extracellular recombinant protein production, the efficiency of five endogenous secretion signal peptides (SPs) of Pichia pastoris, SP13 (MLSTILNIFILLLFIQASLQ), SP23 (MKILSALLLLFTLAFA), SP24 (MKVSTTKFLAVFLLVRLVCA), SP26 (MWSLFISGLLIFYPLVLG), SP34 (MRPVLSLLLLLASSVLA), selected based on their D-score which quantifies the signal peptide-ness of a given sequence segment, was investigated using recombinant human growth hormone (rhGH) as the model protein. The expression was conducted under glyceraldehyde-3-p...
Protease secretion capacity and perforce analysis of recombinant Bacillus species
Çalık, Pınar; Ozdamar, TH (2000-10-08)
Recombinant Bacillus species carrying subC gene encoding serine alkaline protease (SAP) enzyme were developed in order to increase the yield and selectivity in the bioprocess for SAP production. subC gene was amplified from the chromosomal DNA of the wild-type Bacillus licheniformis by using PCR technology; thereafter, subC gene was first cloned into the pRS316 E. coli yeast shuttle plasmid, then sub-cloned into the pHV1431 E. coli-Bacillus shuttle vector, and transferred to the host Bacillus species, i.e. ...
Autocrine TGF-beta and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts
Kojima, Yasushi; Acar, Ahmet; Eaton, Elinor Ng; Mellody, Kieran T.; Scheel, Christina; Ben-Porath, Ittai; Onder, Tamer T.; Wang, Zhigang C.; Richardson, Andrea L.; Weinberg, Robert A.; Orimo, Akira (2010-11-01)
Much interest is currently focused on the emerging role of tumor-stroma interactions essential for supporting tumor progression. Carcinoma-associated fibroblasts (CAFs), frequently present in the stroma of human breast carcinomas, include a large number of myofibroblasts, a hallmark of activated fibroblasts. These fibroblasts have an ability to substantially promote tumorigenesis. However, the precise cellular origins of CAFs and the molecular mechanisms by which these cells evolve into tumor-promoting myof...
Citation Formats
K. F. İzgü, T. Mf, and G. Cm, “Allosuppressor Genes and the Control of Translation Fidelity in Yeast,” 1987, Accessed: 00, 2021. [Online]. Available: