Streptomyces clavuligerus’ta Lysa ve Ccar Genlerinin Sefamisin C Biyosentezi Üzerindeki Etkileri(CCAR VERİLERİ A9 NOLU MAKALENİN BAZI SONUÇLARINI İÇERMEKTEDİR)

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2017-12-03

Author

Otur, Çiğdem
Kurt Kızıldoğan, Aslıhan
Özcengiz, Gülay

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https://hdl.handle.net/11511/76719

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Streptomyces clavuligerus’ta lysaA ve ccarR genlerinin sefamisin C biyosentezi üzerindeki etkileri Özcengiz, Gülay (null; 2017-12-01)
Quantitative expression analysis of the genes potentially involved in clavulanic acid overproduction in streptomyces clavuligerus Aktaş, Caner; Özcengiz, Gülay; Department of Molecular Biology and Genetics (2018) Streptomyces clavuligerus is the producer of the medically important β-lactam antibiotics, including cephamycin C (CC) and the potent β-lactamase inhibitor clavulanic acid. (CA). We have already undertaken an extensive comparative proteomic analysis by using both 2-DE-MALDI-MS and GeLC-MS approaches between an industrial CA overproducer, namely DEPA and the reference strain NRRL3585. In this context, we documented several differentially expressed (over- and under-represented) proteins accounting for high CA...
Effect of homologous multiple copies of aspartokinase gene on cephamycin c biosynthesis in streptomyces clavuligerus Taşkın, Bilgin; Özcengiz, Gülay; Department of Biotechnology (2005) Streptomyces clavuligerus is a gram-positive filamentous bacterium well known for its ability to produce an array of ?-lactam compounds (secondary metabolites) including cephamycin C, clavulanic acid and other structurally related clavams. Of these, cephamycin C is a second generation cephalosporin antibiotic having great medical significance. Biosynthesis of the β-lactam nucleus begins with the non-ribosomal condensation of L-?-aminoadipic acid (?-AAA), L-cysteine and L-valine to form the tripeptide ?-amin...
Cloning and characterization of Streptomyces clavuligerus meso-diaminopimelate decarboxylase (lysA) gene Yağcıoğlu, Çiğdem; Özcengiz, Gülay; Department of Biology (2004) In Streptomyces clavuligerus, the route to the biosynthesis of a-aminoadipic acid (a-AAA) represents an important primary metabolic pathway providing carbon flux to the synthetases of antibiotic formation. This carbon flow comes through the lysine-specific branch of the aspartate pathway and is rate limiting in the formation of cephamycin C, a second generation cephalosporin produced by this organism. In this study, the lysA gene which encodes for an important key enzyme of aspartate pathway; meso-diaminopi...
Targeted disruption of homoserine dehydrogenase gene in Streptomyces clavuligerus and its effects on cephamycin C production Çaydaşı (Koca), Ayşe; Özcengiz, Gülay; Department of Biology (2006) The members of the genus Streptomyces are well-known for their capacity to synthesize a vast repertoire of secondary metabolites, including many useful antibiotics and proteins. Streptomyces clavuligerus is the producer of the medically important β-lactam antibiotics such as cephamycin C and the potent β-lactamase inhibitor clavulanic acid. The aspartate pathway of S. clavuligerus is an important primary metabolic pathway providing substrates for β-lactam synthesis. This pathway uses L-aspartic acid as the ...

Citation Formats

Ç. Otur, A. Kurt Kızıldoğan, and G. Özcengiz, “Streptomyces clavuligerus’ta Lysa ve Ccar Genlerinin Sefamisin C Biyosentezi Üzerindeki Etkileri(CCAR VERİLERİ A9 NOLU MAKALENİN BAZI SONUÇLARINI İÇERMEKTEDİR),” 2017, Accessed: 00, 2021. [Online]. Available: https://hdl.handle.net/11511/76719.