Cancer Drug Discovery: Targeting PI3K/AKT/mTOR Cell Survival Pathway

Atalay, Rengül


Cancer modeling via biologically validated genes
Karakelle, Barış Su; Purutçuoğlu Gazi, Vilda; Ürün, Yüksel (2017-05-10)
The cancer disease is the second most common disease type seen after the frequency of the cardiovascular diseases. The frequency of this genetic disease changes with respect to the gender. Accordingly, the gynecological cancer, which covers ovarian, endometrial or cervical cancer, is the second most common cancer type in women after the breast cancer. Similar to other cancer types, the gynecological cancer is the system disease, meaning that the malfunctions and mutations in the gene regulatory ...
Cancer-testis gene expression is associated with the methylenetetrahydrofolate reductase 677 C>T polymorphism in non-small cell lung carcinoma
Senses, Kerem M; Gonen, Mithat; Barutcu, Ahmet R; Kalaylioglu, Zeynep; Isbilen, Murat; Konu, Ozlen; Senses, Kerem M; Chen, Yao T; Altorki, Nasser K; Gonen, Mithat; Gure, Ali O; Barutcu, Ahmet R; Kalaylioglu, Zeynep; Isbilen, Murat; Konu, Ozlen; Chen, Yao T; Altorki, Nasser K; Gure, Ali O (Springer Science and Business Media LLC, 2013-9-24)
Background: Tumor-specific, coordinate expression of cancer-testis (CT) genes, mapping to the X chromosome, is observed in more than 60% of non-small cell lung cancer (NSCLC) patients. Although CT gene expression has been unequivocally related to DNA demethylation of promoter regions, the underlying mechanism leading to loss of promoter methylation remains elusive. Polymorphisms of enzymes within the 1-carbon pathway have been shown to affect S-adenosyl methionine (SAM) production, which is the sole methyl ...
Cancer onset and progression: A genome-wide, nonlinear dynamical systems perspective on onconetworks
Qu, K.; Haidar, A. Abi; Fan, J.; Ensman, L.; Tuncay, Kağan; Jolly, M.; Ortoleva, P. (Elsevier BV, 2007-05-21)
It is hypothesized that the many human cell types corresponding to multiple states is supported by an underlying nonlinear dynamical system (NDS) of transcriptional regulatory network (TRN) processes. This hypothesis is validated for epithelial cells whose TRN is found to support an extremely complex array of states that we term a "bifurcation nexus", for which we introduce a quantitative measure of complexity. The TRN used is constructed and analyzed by integrating a database of TRN information, cDNA micro...
Stem cell based nerve tissue engineering on guided constructs
Yücel, Deniz; Hasırcı, Vasıf Nejat; Department of Biotechnology (2009)
Nerve injury is a serious clinical problem that has a direct impact on the quality of life. Nerve tissue engineering (NTE) is one of the most promising methods in human health care to restore the function of damaged neural tissues. The current state of the art involves the construction of a tissue engineered, nano or micropatterned 3-D nerve tube that has fibers or channels in the inside. The scope of this study is to construct a 3-D, biodegradable nerve tube which consists of an aligned, electrospun mat se...
Stem Cell and Advanced Nano Bioceramic Interactions
Kose, Sevil; Kankilic, Berna; Gizer, Merve; Dede, Eda Ciftci; Bayramlı, Erdal; KORKUSUZ, PETEK; KORKUSUZ, FEZA (2018-01-01)
Bioceramics are type of biomaterials generally used for orthopaedic applications due to their similar structure with bone. Especially regarding to their osteoinductivity and osteoconductivity, they are used as biodegradable scaffolds for bone regeneration along with mesenchymal stem cells. Since chemical properties of bioceramics are important for regeneration of tissue, physical properties are also important for cell proliferation. In this respect, several different manufacturing methods are used for manuf...
Citation Formats
R. Atalay, “Cancer Drug Discovery: Targeting PI3K/AKT/mTOR Cell Survival Pathway,” 2017, Accessed: 00, 2021. [Online]. Available: