Streptomyces clavuligerus’ta lysaA ve ccarR genlerinin sefamisin C biyosentezi üzerindeki etkileri

Date

2017-12-01

Author

Özcengiz, Gülay

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Subject Keywords

Streptomyces clavuligerus, Sefamisin C, Lysa, ccaR

URI

http://www.biyoteknolojikongre.com/uploads/bildiri-kitapcigi-17.pdf
https://hdl.handle.net/11511/77578

Conference Name

19. Uluslararası Katılımlı Ulusal Biyoteknoloji Kongresi

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Department of Biology, Conference / Seminar

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Quantitative expression analysis of the genes potentially involved in clavulanic acid overproduction in streptomyces clavuligerus Aktaş, Caner; Özcengiz, Gülay; Department of Molecular Biology and Genetics (2018) Streptomyces clavuligerus is the producer of the medically important β-lactam antibiotics, including cephamycin C (CC) and the potent β-lactamase inhibitor clavulanic acid. (CA). We have already undertaken an extensive comparative proteomic analysis by using both 2-DE-MALDI-MS and GeLC-MS approaches between an industrial CA overproducer, namely DEPA and the reference strain NRRL3585. In this context, we documented several differentially expressed (over- and under-represented) proteins accounting for high CA...
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Effect of homologous multiple copies of aspartokinase gene on cephamycin c biosynthesis in streptomyces clavuligerus Taşkın, Bilgin; Özcengiz, Gülay; Department of Biotechnology (2005) Streptomyces clavuligerus is a gram-positive filamentous bacterium well known for its ability to produce an array of ?-lactam compounds (secondary metabolites) including cephamycin C, clavulanic acid and other structurally related clavams. Of these, cephamycin C is a second generation cephalosporin antibiotic having great medical significance. Biosynthesis of the β-lactam nucleus begins with the non-ribosomal condensation of L-?-aminoadipic acid (?-AAA), L-cysteine and L-valine to form the tripeptide ?-amin...
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Citation Formats

G. Özcengiz, “Streptomyces clavuligerus’ta lysaA ve ccarR genlerinin sefamisin C biyosentezi üzerindeki etkileri,” presented at the 19. Uluslararası Katılımlı Ulusal Biyoteknoloji Kongresi, Eskişehir, Türkiye, 2017, Accessed: 00, 2021. [Online]. Available: http://www.biyoteknolojikongre.com/uploads/bildiri-kitapcigi-17.pdf.