Streptomyces clavuligerus’ta lysaA ve ccarR genlerinin sefamisin C biyosentezi üzerindeki etkileri

2017-12-01

Suggestions

Implementation of a closed-loop action generation system on a humanoid robot through learning by demonstration
Tunaoğlu, Doruk; Şahin, Erol; Department of Computer Engineering (2010)
In this thesis the action learning and generation problem on a humanoid robot is studied. Our aim is to realize action learning, generation and recognition in one system and our inspiration source is the mirror neuron hypothesis which suggests that action learning, generation and recognition share the same neural circuitry. Dynamic Movement Primitives, an efficient action learning and generation approach, are modified in order to fulfill this aim. The system we developed (1) can learn from multiple demonstr...
Quantitative expression analysis of the genes potentially involved in clavulanic acid overproduction in streptomyces clavuligerus
Aktaş, Caner; Özcengiz, Gülay; Department of Molecular Biology and Genetics (2018)
Streptomyces clavuligerus is the producer of the medically important β-lactam antibiotics, including cephamycin C (CC) and the potent β-lactamase inhibitor clavulanic acid. (CA). We have already undertaken an extensive comparative proteomic analysis by using both 2-DE-MALDI-MS and GeLC-MS approaches between an industrial CA overproducer, namely DEPA and the reference strain NRRL3585. In this context, we documented several differentially expressed (over- and under-represented) proteins accounting for high CA...
Streptomyces clavuligerus’ta Lysa ve Ccar Genlerinin Sefamisin C Biyosentezi Üzerindeki Etkileri(CCAR VERİLERİ A9 NOLU MAKALENİN BAZI SONUÇLARINI İÇERMEKTEDİR)
Otur, Çiğdem; Kurt Kızıldoğan, Aslıhan; Özcengiz, Gülay (2017-12-03)
Effect of homologous multiple copies of aspartokinase gene on cephamycin c biosynthesis in streptomyces clavuligerus
Taşkın, Bilgin; Özcengiz, Gülay; Department of Biotechnology (2005)
Streptomyces clavuligerus is a gram-positive filamentous bacterium well known for its ability to produce an array of ?-lactam compounds (secondary metabolites) including cephamycin C, clavulanic acid and other structurally related clavams. Of these, cephamycin C is a second generation cephalosporin antibiotic having great medical significance. Biosynthesis of the β-lactam nucleus begins with the non-ribosomal condensation of L-?-aminoadipic acid (?-AAA), L-cysteine and L-valine to form the tripeptide ?-amin...
Targeted disruption of homoserine dehydrogenase gene in Streptomyces clavuligerus and its effects on cephamycin C production
Çaydaşı (Koca), Ayşe; Özcengiz, Gülay; Department of Biology (2006)
The members of the genus Streptomyces are well-known for their capacity to synthesize a vast repertoire of secondary metabolites, including many useful antibiotics and proteins. Streptomyces clavuligerus is the producer of the medically important β-lactam antibiotics such as cephamycin C and the potent β-lactamase inhibitor clavulanic acid. The aspartate pathway of S. clavuligerus is an important primary metabolic pathway providing substrates for β-lactam synthesis. This pathway uses L-aspartic acid as the ...
Citation Formats
G. Özcengiz, “Streptomyces clavuligerus’ta lysaA ve ccarR genlerinin sefamisin C biyosentezi üzerindeki etkileri,” presented at the 19. Uluslararası Katılımlı Ulusal Biyoteknoloji Kongresi, Eskişehir, Türkiye, 2017, Accessed: 00, 2021. [Online]. Available: http://www.biyoteknolojikongre.com/uploads/bildiri-kitapcigi-17.pdf.