Asymmetric organocatalytic Michael additions of thioglycolic esters to various acceptors

Hasılcıoğulları, Deniz
Tanyeli, Cihangir


Asymmetric organocatalytic Michael additions of methyl thioglycolate to various acceptors
Tözendemir, Deniz; Tanyeli, Cihangir (2017-04-06)
Asymmetric organocatalytic sulfa-michael reactions of thioglycolate with isatin derived nitroalkenes
Sağesen, Selin; Tanyeli, Cihangir; Department of Chemistry (2018)
Organosulfur compounds are present in many natural products and drugs. Sulfa-Michael reaction is the prominent method to synthesize these molecules. The novel bifuctional organocatalysts developed in our research group enable sulfa-Michael reaction to ocur asymmetrically. In this thesis, biologically active isatin derived nitroalkenes were chosen as Sulfa-Michael acceptors. Addition of methyl thioglycolate to isatin derived nitroalkenes in the presence of the bifunctional organocatalysts was studied under d...
Asymmetric aldol addition of alpha-azido ketones to ethyl pyruvate mediated by a cinchona-based bifunctional urea catalyst
Okumus, Seda; Tanyeli, Cihangir; Demir, Ayhan Sıtkı (Elsevier BV, 2014-07-30)
The first asymmetric synthesis of ethyl 4-aryl-3-azido-2-hydroxy-2-methyl-4-oxobutanoates via a cinchona organocatalyst induced aldol addition of alpha-azido ketones to ethyl pyruvate has been developed. The coupling reaction under optimized conditions was carried out to furnish tetrafunctionalized synthons with enantioselectivities of up to 91:9 and enriched diastereoselectivities of up to 95:5 (syn:anti).
Asymmetric Michael addition of aldehydes to nitroolefins with l-proline and bifunctional organocatalyst combination
İşibol, Duygu; Demir, Ayhan Sıtkı; Tanyeli, Cihangir; Department of Chemistry (2013)
Since their serendipitously discovery in 1993, hydrogel of self-assembling peptides are becoming an emerging field especially in last 10 years. For their application in selective drug delivery, tissue engineering and biomedical applications, divergent peptide libraries can be constructed through chemical peptide synthesis, utilizing synthetic amino acids addition to 21 naturally occurring ones. One of the methods which were applied to obtain self-assembling peptides is incorporating strongly beta-sheet form...
Asymmetric diethylzinc addition to N-sulphonyl and N-phosphinoyl arylaldimines
Çağlı, Eda; Doğan, Özdemir; Department of Chemistry (2013)
Design of new chiral ligands for asymmetric synthesis is important. The ligand should be economical and efficient in enantioselective transformations. For the synthesis of some natural products and biologically active compounds, optically active amines are used as important intermediates. For this reason, it is significant to develop new catalyst system which can produce optically active amines in an economical and efficient way. Our group developed PFAM ligands and used successfully for the enantioselectiv...
Citation Formats
D. Hasılcıoğulları and C. Tanyeli, “Asymmetric organocatalytic Michael additions of thioglycolic esters to various acceptors,” presented at the ACS 253rd National Meeting, ( 02 Nisan 2017 - 06 Nisan 2016), San-Francisco, Kostarika, 2017, Accessed: 00, 2021. [Online]. Available: