Genome Wide Evolutionary Analyses Reveal Serotypes Specific Patterns of Positive Selection in Selected Salmonella Serotypes

Soyer, Yeşim
Sun, Q
Wiedmann, M


Genome wide evolutionary analyses reveal serotype specific patterns of positive selection in selected Salmonella serotypes
Soyer, Yeşim; Rodriguez-Rivera, Lorraine D.; Sun, Qi; Wiedmann, Martin (Springer Science and Business Media LLC, 2009-11-14)
Background: The bacterium Salmonella enterica includes a diversity of serotypes that cause disease in humans and different animal species. Some Salmonella serotypes show a broad host range, some are host restricted and exclusively associated with one particular host, and some are associated with one particular host species, but able to cause disease in other host species and are thus considered "host adapted". Five Salmonella genome sequences, representing a broad host range serotype (Typhimurium), two host...
Genome-wide variation analysis of formalin fixed paraffin embedded pulmonary metastatic tumor samples of osteosarcoma patients
Nil, Zelha; Gündüz, Ufuk; Department of Biology (2012)
Osteosarcoma (OS) is a type of cancer that starts in the bone. It generally occurs in the cells called osteoblasts which form matrix of the bone. It is the most common malignant tumor of bone with an incidence rate of 19% among all cancer types. The vast majority of OS patients have pulmonary metastases at the time they are diagnosed, and about half develop lung disease later. Moreover, pulmonary metastatic tumors lead to poor prognosis and increased death rate. Although mutations in the genes coding for p5...
Genome-Scale Networks Link Neurodegenerative Disease Genes to α-Synuclein through Specific Molecular Pathways.
KHURANA, V; et. al. (2017-02-22)
Numerous genes and molecular pathways are implicated in neurodegenerative proteinopathies, but their inter-relationships are poorly understood. We systematically mapped molecular pathways underlying the toxicity of alpha-synuclein (alpha-syn), a protein central to Parkinson's disease. Genome-wide screens in yeast identified 332 genes that impact alpha-syn toxicity. To "humanize'' this molecular network, we developed a computational method, Transpose Net. This integrates a Steiner prize-collecting approach w...
Genome analysis of antimicrobial resistance, virulence, and plasmid presence in Turkish Salmonella serovar Infantis isolates
Acar, Sinem; Bulut, Ece; Stasiewicz, Matthew J.; Soyer, Yeşim (2019-10-16)
Salmonella enterica subsp. enterica serovar Infantis (S. Infantis) isolates were found to have a multi-drug resistance profile (kanamycin, streptomycin, nalidixic acid, tetracycline, sulfonamide, and sometimes to ampicillin) and high prevalence (91%) in Turkish poultry in our previous studies. To investigate the mechanism behind multi-drug antimicrobial resistance (AMR) and high prevalence in Turkish poultry, 23 of the isolates were sequenced for comparative genomic analyses including: SNP-based comparison ...
Genome-Wide Transcriptional Reorganization Associated with Senescence-to-Immortality Switch during Human Hepatocellular Carcinogenesis
Yildiz, Gokhan; ARSLAN ERGÜL, AYÇA; Bagislar, Sevgi; KONU KARAKAYALI, ÖZLEN; Yuzugullu, Haluk; Gursoy-Yuzugullu, Ozge; Ozturk, Nuri; Özen, Çiğdem; ÖZDAĞ, Hilal; Erdal, Esra; KARADEMİR, SEDAT; SAĞOL, ÖZGÜL; Mizrak, Dilsa; BOZKAYA, HAKAN; İLK, HAKKI GÖKHAN; İlk Dağ, Özlem; Bilen, Biter; Atalay, Rengül; Akar, Nejat; Ozturk, Mehmet (Public Library of Science (PLoS), 2013-05-15)
Senescence is a permanent proliferation arrest in response to cell stress such as DNA damage. It contributes strongly to tissue aging and serves as a major barrier against tumor development. Most tumor cells are believed to bypass the senescence barrier (become "immortal") by inactivating growth control genes such as TP53 and CDKN2A. They also reactivate telomerase reverse transcriptase. Senescence-to-immortality transition is accompanied by major phenotypic and biochemical changes mediated by genome-wide t...
Citation Formats
Y. Soyer, Q. Sun, and M. Wiedmann, “Genome Wide Evolutionary Analyses Reveal Serotypes Specific Patterns of Positive Selection in Selected Salmonella Serotypes,” 2009, Accessed: 00, 2021. [Online]. Available: