METAL CATALYZED ASYMMETRIC SYNTHESIS OF HETEROARYL SUBSTITUTED PYRROLIDINES

Date

2019-09-21

Author

Doğan, Özdemir
Gözükara, Zeynep
Aras, Mihrimah
Polat Çakır, Sıdıka

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https://hdl.handle.net/11511/80543

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Metal catalyzed asymmetric synthesis of heteroaryl substitıted pyrolidines Doğan, Özdemir; Gözükara, Zeynep; Araz, Mihrimah; Polat Çakır, Sıdıka (null; 2019-10-15)
Metal catalyzed asymmetric synthesis of thienyl-substituted pyrrolidines by 1,3-dipolar cycloaddition reaction of azomethine ylides Bulut, Merve; Doğan, Özdemir; Department of Chemistry (2019) Pyrrolidines are structurally and biologically important heterocyclic compounds. One of the efficient methods for the synthesis of these compounds is 1,3-dipolar cycloaddition (1,3-DC) reaction of azomethine ylides with electron deficient dipolarophiles. Asymmetric synthesis of these compounds has been studied by many groups by using 1,3-DC reactions with chiral transition metal catalysts. In all these studies aryl-substituted pyrrolidines were synthesized mainly. In this thesis, heteroaryl-substituted pyrr...
Metal catalyzed 1,3-dipolar cycloaddition reaction of azomethine ylides enantioselective synthesis of heteroaryl substituted prrolidines Doğan, Özdemir (null; 2018-09-05)
Metal catalyzed and organocatalytic asymmetric synthesis Doğan, Özdemir (null; 2015-09-07)
Metal triflates-catalyzed conjugate addition of homochiral Pyrroles to alpha,beta-unsaturated esters Unaleroglu, C; Temelli, B; Demir, Ayhan Sıtkı (Georg Thieme Verlag KG, 2004-10-18) The Friedel-Crafts reaction of homochiral pyrrole derivatives with alpha,beta-unsaturated esters catalyzed by metal triflates furnished conjugate addition products. The best yields were obtained by using yttrium triflate and methyl 4-phenyl-2-oxobut-3-enoate (2a). The addition worked regioselectively at C-5 of pyrrole. The diastereoisomers were separated by column chromatography.

Citation Formats

Ö. Doğan, Z. Gözükara, M. Aras, and S. Polat Çakır, “METAL CATALYZED ASYMMETRIC SYNTHESIS OF HETEROARYL SUBSTITUTED PYRROLIDINES,” 2019, Accessed: 00, 2021. [Online]. Available: https://hdl.handle.net/11511/80543.