Detection of the relationship between thrombophilia disease with genetic disorders by adaptive neuro-fuzzy inference system (ANFIS)

Date

2016-04-01

Author

Haznedar, Bülent
Kalınlı, Adem

Metadata

Show full item record

Item Usage Stats

50
views

0
downloads

Kanın damar içinde ya da bir organda pıhtılaşması olan Tromboz’a yol açan hastalıklarda önemli sağlık sorunları ortaya çıkmakta ve hatta birçok vakada insanlar hayatını kaybedebilmektedir. Tromboz gelişimi multifaktoriyel olup, çok sayıda edinsel ve kalıtsal faktörün değişik mekanizmalarla tromboz oluşumuna neden olduğu bilinmekte ise de tromboza yatkınlık olarak bilinen Trombofili tanısının konmasında önemli zorluklar yaşanmaktadır. Bu kapsamda, geleneksel sınıflandırma yöntemlerinin klinik, laboratuvar ve genetik tetkiklere ait verilerin değerlendirilmesindeki başarımları ise çoğunlukla sınırlı kalabilmektedir. Bu çalışmada, Trombofili hastalığı ile genetik bozukluklar arasındaki ilişkinin tespit edilebilmesi için Adaptif Ağ Tabanlı Bulanık Mantık Çıkarım Sistemi (ANFIS) kullanılmış ve elde edilen sonuçlar literatürde yaygın olarak kullanılan bazı sınıflandırma algoritmalarına ait sonuçlarla karşılaştırılmıştır. Elde edilen sonuçlardan, ANFIS ile elde edilen sonuçların daha başarılı olduğu görülmüştür.

Subject Keywords

ANFIS, Tromboz

URI

https://hdl.handle.net/11511/80680

Journal

SAKARYA UNİVERSİTY JOURNAL OF SCİENCE

Collections

Unverified, Article

Suggestions

OpenMETU
Core

DETECTION OF CIRCULAR RNAS IN HEPATOCELLULAR CARCINOMA TREATED WITH DIFFERENT THERAPEUTIC AGENTS USING RNA-SEQ DATA Tamkoç, Burcu; Acar, Aybar Can; Özen, Can; Department of Biotechnology (2021-9-8) Discovering therapeutic agents for hepatocellular carcinoma (HCC) pose challenges as HCC contains high heterogeneity in terms of molecular phenotypes. It is thus crucial to understand the role of circular RNAs in the treatment of HCC. Circular RNAs are small and non-coding endogenous RNAs that have single stranded and covalently bound structures. The clinical importance of circular RNAs is due to their high stability in the serum and tissue. Up to now, the detection of circular RNAs was done through specifi...
Development of new synthetic strategies for aminocyclitols Demir (Davulcu), Emine; Balcı, Metin; Department of Chemistry (2003) Cyclitols are of great importance due to their biological activities playing a crucial role in living organisms as well as their synthetic usefulness in the synthesis of other natural compounds or pharmaceuticals. In this study, new synthetic strategies leading to the aminocyclitols were investigated. The synthesis of aminoconduritol and aminoinositol derivatives (173 and 174) were achieved starting from easily available compound, 7-oxa-bicyclo[2.2.1]hept-5-ene-2,3-dicarboxylic anhydride (166) obtained from...
ENRICHMENT OF DENITRIFYING ANAEROBIC METHANE OXIDATION (DAMO) AND ANAEROBIC AMMONIUM OXIDATION (ANAMMOX) CO-CULTURE FOR THE TREATMENT OF ANAEROBIC DIGESTER EFFLUENT Harb, Rayaan; Bayramoğlu, Tuba Hande; Department of Environmental Engineering (2023-1-20) Recently, the implementation of next-generation biological nutrient removal techniques aimed at recycling nutrients such as nitrogen and phosphorus while generating energy, producing value-added products and mitigating greenhouse gas emissions, in wastewater treatment plants is being emphasized. In this regard, investigating the development and applicability of a DAMO-Anammox co-culture and a novel DAMO-Anammox-Microalgae sequential treatment unit in the treatment of anaerobic digester (AD) effluent was the...
Selecting 2-FY RNA Aptamers Against SARS-CoV-2 Particle Öztürk, Meriç; Gözen, Ayşe Gül; İlgü, Müslüm; Department of Molecular Biology and Genetics (2021-6-22) Corona Virus Disease – 19 (COVID-19) is caused by infection of SARS-CoV-2 from other humans and animals, which results in clinical symptoms like fever, cough, breathing difficulties headache, muscle pain, and diarrhea. Further symptoms can be life threatening clinical conditions such as pneumonia, cardiovascular and rarely neurological complexities. According to studies, estimated fatality rate of the disease is about 4 %; reported cases-fatality rate is about 2.3 %. Early diagnosis is crucial to prevent fu...
SELECTION OF 2'FY RNA APTAMERS AGAINST CRIMEAN CONGO HAEMORRHAGIC FEVER VIRUS ARDIÇ, FUNDA ZEKİYE; Gözen, Ayşe Gül; İlgü, Müslüm; Department of Molecular Biology and Genetics (2022-2-11) Crimean-Congo hemorrhagic fever (CCHF) is potentially lethal and mostly infected by ticks. CCHF virus (CCHFV), is a Nairoviridae family member of the Orthonairovirus genus and in general, cases are reported from Asia, Africa, the Middle East, and Eastern Europe. The fatality rate ranges from 30 to 50% worldwide but it is reported as 5% by the Turkish Ministry of Health and it varies between 1.7 and 26.5% for children. ELISA kits used for the detection of infection are time-consuming, expensive, and labor-in...

Citation Formats

B. Haznedar and A. Kalınlı, “Detection of the relationship between thrombophilia disease with genetic disorders by adaptive neuro-fuzzy inference system (ANFIS),” SAKARYA UNİVERSİTY JOURNAL OF SCİENCE, pp. 13–21, 2016, Accessed: 00, 2021. [Online]. Available: https://hdl.handle.net/11511/80680.