Analysis of Protein and mRNA Expressions of NQO1 and GST pi Enzymes in Liver Colon and Prostate Cancer Cell Lines to Study Drug and and Carcinogen Metabolism

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2016-09-01

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Evin, Emre
Adalı, Orhan

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https://hdl.handle.net/11511/80902

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Analysis of protein and mRNA expressions of NQO1 and GST-pi enzymes in liver, colon and prostate cancer cell lines to study drug and carcinogen metabolism Evin, Emre; Adalı, Orhan (2016-09-01)
Analysis of Protein and mRNA Expressions of CYP1A1 and CYP2E1 Enzymes In Liver, Colon And Prostate Cancer Cell Lines to Study Drug and Carcinogen Metabolism Evin, Emre; Akkulak, Merve; Adalı, Orhan (null; 2017-10-29) Most of the marketed drugs are metabolized by Cytochrome P450s (CYPs) known as phase I enzymes. A phase I enzyme, CYP1A1 catalyzes the conversion of many pro-carcinogens and hydroxylation of many endogenous substrates. CYP2E1 is also important in the metabolism of drugs, pre-toxins and pro-carcinogens. The present study was aimed to describe the best cell line model for studying phase I xenobiotic metabolizing CYP1A1 and CYP2E1 enzymes and possible effects of xenobiotics on these enzymes. In this study HT29...
Analysis of protein and mRNA expressions of CYP1A1, CYP2E1, NQO1 and GST enzymes in liver, colon and prostate cancer cell lines to study drug and carcinogen metabolism Evin, Emre; Adalı, Orhan; Karakurt, Serdar; Department of Biochemistry (2014) Xenobiotic metabolism is the combination of phase I and phase II reactions which are named as modification and conjugation reactions, respectively. Most of the marketed drugs are metabolized by Cytochrome P450s (CYPs) known as phase I enzymes. CYP1A1 and CYP2E1 enzymes play role in activation/inactivation of many drugs and carcinogens. Phase II enzymes including NQO1 and GSTP1 are important for the elimination of toxic metabolites by reduction and conjugation reactions, respectively. Since in vitro studies ...
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Citation Formats

E. Evin and O. Adalı, “Analysis of Protein and mRNA Expressions of NQO1 and GST pi Enzymes in Liver Colon and Prostate Cancer Cell Lines to Study Drug and and Carcinogen Metabolism,” 2016, Accessed: 00, 2021. [Online]. Available: https://hdl.handle.net/11511/80902.