Vancomycin resistance genes reservoired and disseminated in surface waters



Vancomycin containing PLLA/beta-TCP controls experimental osteomyelitis in vivo
Kankilic, Berna; BİLGİÇ, ELİF; KORKUSUZ, PETEK; Korkusuz, Feza (2014-11-19)
Background: Implant-related osteomyelitis (IRO) is recently controlled with local antibiotic delivery systems to overcome conventional therapy disadvantages. In vivo evaluation of such systems is however too little.
Vancomycin release from poly(D,L-lactide) and poly(lactide-co-glycolide) disks
Ozalp, Y; Ozdemir, N; Hasırcı, Vasıf Nejat (2002-01-01)
A biodegradable and biocompatible polymeric system was developed for the controlled release of vancomycin for the treatment of brain abscesses. Poly(D,L-lactic acid) (PLA) and its copolymers poly( lactide-co-glycolide) PLGA 90: 10 and PLGA 70: 30, were prepared. Polymer disks containing vancomycin (VN) were prepared by solvent casting from methylene chloride solutions. Degradation of the polymer disk was studied by scanning electron microscopy, NMR and GPC. SEM revealed an increasing degree of degradation w...
Vancomycin Containing PDLLA and PLGA/β-TCP Inhibit Biofilm Formation but Do Not Stimulate Osteogenic Transformation of Human Mesenchymal Stem Cells
Kankilic, Berna; Bayramlı, Erdal; KORKUSUZ, PETEK; EROĞLU, HAKAN; ŞENER, BURÇİN; Mutlu, Pelin; KORKUSUZ, FEZA (2022-07-01)
Aims: Chronic osteomyelitis, including implant-related prosthetic joint infection, is extremely difficult to cure. We develop vancomycin containing release systems from poly(d,l-lactide) (PDLLA) and poly(d,l-lactide-co-glycolide) (PLGA) composites with beta-tricalcium phosphate (β-TCP) to treat methicillin-resistant Staphylococcus aureus osteomyelitis. We ask whether vancomycin containing PDLLA/β-TCP and PLGA/β-TCP composites will prevent early biofilm formation, allow cell proliferation and osteogenic diff...
Vancomycin containing plla delivery system for bone tissue biocompatibility and treatment of implant related chronic osteomyelitis
Uysal, Berna; Korkusuz, Feza; Department of Biotechnology (2009)
Osteomyelitis is an infection of bone or bone marrow, usually caused by pyogenic bacteria. It can cultivate by hematogen way or it can cultivate by the help of local soft tissue infection. Osteomyelitis often requires prolonged antibiotic therapy and surgery. But for therapy; antibiotic must reach to effective dose in the bone. So that; for prevention and treatment of osteomyelitis controlled antibiotic release systems can be used. These systems have been developed to deliver antibiotics directly to infecte...
Vanadium toxicity in chickpea (Cicer arietinum L.) grown in red soil: Effects on cell death, ROS and antioxidative systems
Imtiaz, Muhammad; Ashraf, Muhammad; Rizwan, Muhammad Shahid; Nawaz, Muhammad Amjad; Rizwan, Muhammad; Mehmood, Sajid; Yousaf, Balal; Yuan, Yuan; Ditta, Allah; Mumtaz, Muhammad Ali; Ali, Muhammad; Mahmood, Sammina; Tu, Shuxin (2018-08-01)
The agricultural soil contaminated with heavy metals induces toxic effects on plant growth. The present study was conducted to evaluate the effects of vanadium (V) on growth, H2O2 and enzyme activities, cell death, ion leakage, and at which concentration; V induces the toxic effects in chickpea plants grown in red soil. The obtained results indicated that the biomass (fresh and dry) and lengths of roots and shoots were significantly decreased by V application, and roots accumulated more V than shoots. The e...
Citation Formats
M. Nakipoğlu and B. İçgen, “Vancomycin resistance genes reservoired and disseminated in surface waters,” 2015, Accessed: 00, 2021. [Online]. Available: