Association analysis of CYP24A1 rs927650 polymorphism and ischemic stroke risk in Turkish Population

Date

2015-08-25

Author

Bilgin, Esra
Tuğçe, Öner
Can Demirdöğen, Birsen
Adalı, Orhan

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https://hdl.handle.net/11511/82452

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Association analysis of glutathione s-transferase omega 1 and omega 2 genetic polymorphisms and ischemic stroke risk in Turkish population Bilgin, Esra; Adalı, Orhan; Department of Biochemistry (2014) Stroke is defined as the acute neurological cerebrovascular disease based on interruptions to blood flow in the brain. These interruptions are caused by loss of blood supply due to vessel bursts or vessel blocked by clotting. Atherosclerosis, a main cause of stroke, is blockage of endothelium layer of arteries and losing the flexibility of tissue. The oxidative stress is known as a risk factor for atherosclerosis. The increased free radicals such as reactive oxygen species (ROS) and decreased antioxidant le...
Association analysis of cholesterol 7-alpha hydroxylase (CYP7A1)and cholesterol 24-hydroxlase (CYP46A1) genetic polymorphisms and multiple sclerosis risk in Turkish population Sezer, Eda; Kaya, Zeki; Department of Molecular Biology and Genetics (2019) Multiple Sclerosis (MS) is the most common demyelinating disorder of the central nervous system. Under the effects of certain environmental factors, MS develops in genetically susceptible individuals. People with MS have significantly lower vitamin D levels. UV-B radiation catalyzes the photo-conversion of 7-dehydrocholesterol, produced in cholesterol production pathway, to vitamin D in the skin. Cholesterol 7α-hydroxylase (CYP7A1) in the liver and Cholesterol 24S-hydroxylase (CYP46A1) in the brain are resp...
Association analysis of Glutathione S-transferase omega-1 and omega-2 genetic polymorphisms and ischemic stroke risk in a Turkish population Bilgin, Esra; Can Demirdöğen, Birsen; Ozcelik, Aysun Turkanoglu; Demirkaya, Seref; Adalı, Orhan (Informa UK Limited, 2019-01-01) Objectives: Oxidative stress is a known risk factor for the pathogenesis of atherosclerosis, the main cause of ischemic stroke. Glutathione S-transferase (GST) omega-1 and omega-2, members of phase II enzymes, play a role in the antioxidant system. The single nucleotide polymorphisms (SNPs), C419A and A424G in GST omega genes can cause a decrease in enzyme activity. The aim of this study was to investigate the possible association between these polymorphisms and ischemic stroke risk in a Turkish population.
Association analysis of GSTT1, GSTM1 genotype polymorphisms and serum total GST activity with ischemic stroke risk Turkanoglu, Aysun; Demirdogen, Birsen Can; Demirkaya, Seref; Bek, Semai; Adalı, Orhan (Springer Science and Business Media LLC, 2010-12-01) Oxidative stress plays a major role in pathogenesis of atherosclerosis which is responsible for stroke. Glutathione S-transferases (GSTs) detoxify metabolites produced by oxidative stress within the cell and protect the cells against injury. This study aimed to investigate the association of polymorphisms in GSTT1, GSTM1 genes and GST activity with ischemic stroke risk. Patients had almost the same GST activity as that of controls. No significant differences were found between patients and controls in terms...

Citation Formats

E. Bilgin, Ö. Tuğçe, B. Can Demirdöğen, and O. Adalı, “Association analysis of CYP24A1 rs927650 polymorphism and ischemic stroke risk in Turkish Population,” 2015, Accessed: 00, 2021. [Online]. Available: https://hdl.handle.net/11511/82452.