Osteoconductivity of layer-by-layer films of poly(4-hydroxy-L-proline) ester

Date

2017-06-21

Author

Onat, Bora
Özçubukçu, Salih
Banerjee, Sreeparna
Erel Göktepe, İrem

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https://hdl.handle.net/11511/83574

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Osteoconductive layer-by-layer films of Poly(4-hydroxy-L-proline ester) (PHPE) and Tannic acid Onat, Bora; Özçubukçu, Salih; Banerjee, Sreeparna; Erel Göktepe, İrem (Elsevier BV, 2018-06-01) Orthopedic implants have shown major success in clinics after successful orthopedic surgeries. However, they are also associated with several drawbacks such as local and systemic immune reaction in the body and improper integration of the bone with the implants. Osteoconductivity is a property of orthopedic implants that promotes bone cell adhesion and bone tissue integration on implant surfaces. This study presents use of a biodegradable cationic polyester, poly(4-hydroxy-L-proline ester) (PHPE) together w...
Osteogenic differentiation of MC3T3-E1 cells on different titanium surfaces HAKKI, SEMA; Bozkurt, S. Buket; HAKKI, ERDOĞAN EŞREF; KORKUSUZ, PETEK; PURALI, NUHAN; Koc, Nursen; Timucin, Muharrem; ÖZTÜRK, ADNAN; Korkusuz, Feza (IOP Publishing, 2012-08-01) mRNA expressions related to osteogenic differentiation of MC3T3-E1 cells on electro-polished smooth (S), sandblasted small-grit (SSG) and sandblasted large-grit (SLG) surfaces of titanium alloys were investigated in vitro. Gene expression profiles of cells were evaluated using the RT2 Profiler PCR microarray on day 7. Mineralizing tissue-associated proteins, differentiation factors and extracellular matrix enzymes mRNA expressions were measured using Q-PCR. SLG surface upregulated 23 genes over twofolds and...
Immobilization of catalase in poly(isopropylacrylamide-co-hydroxyethylmethacrylate) thermally reversible hydrogels Arica, MY; Öktem, Hüseyin Avni; Oktem, Z; Tuncel, SA (1999-09-01) Catalase was entrapped in thermally reversible poly (isopropylacrylamide-co-hydroxyethyl-methacrylate) (pNIPAM/HEMA) copolymer hydrogels. The thermoresponsive hydrogels, in cylindIl-rical geometry, were prepared in an aqueous buffer by redox polymerization. It was observed that upon entrapment, the activity retention of catalase was decreased between 47 and 14%, and that increasing the catalase loading of hydrogel adversely affected the activity. The kinetic behaviour of the entrapped enzyme was investigate...
Immobilization of invertase in conducting polypyrrole polytetrahydrofuran graft polymer matrices Kizilyar, N; Akbulut, Ural; Toppare, Levent Kamil; Ozden, MY; Yagci, Y (1999-06-24) Four different polypyrrole/polytetrahydrofuran/invertase electrodes were constructed by the entrapment of invertase in conducting polymer matrices via electropolymerization. Immobilization of the enzyme was achieved by the application of a 1.1 V constant potential to a platinum electrode for 30 min in a solution containing 0.01 M pyrrole, 0.4 mg/ml invertase and 0.4 mg/ml sodium dodecyl sulphate. Performance of each electrode was optimized by examining the effects of pH and temperature on the properties of ...
Immobilization of invertase in conducting polymer matrices Selampinar, F; Akbulut, Ural; Ozden, MY; Toppare, Levent Kamil (1997-09-01) This paper reports a novel approach in the electrode immobilization of an enzyme, invertase, by electrochemical polymerization of pyrrole in the presence of enzyme. The polypyrrole/invertase and polyamide/polypyrrole/invertase electrodes were constructed by the entrapment of enzyme in conducting matrices during electrochemical polymerization of pyrrole. This study involves the preparation and characterization of polypyrrole/invertase and polyamide/polypyrrole/invertase electrodes under conditions compatible...

Citation Formats

B. Onat, S. Özçubukçu, S. Banerjee, and İ. Erel Göktepe, “Osteoconductivity of layer-by-layer films of poly(4-hydroxy-L-proline) ester,” 2017, Accessed: 00, 2021. [Online]. Available: https://hdl.handle.net/11511/83574.